来自越南酒饼叶果实的细胞毒性吲哚生物碱。

Cytotoxic indole alkaloids from the fruits of Melodinus cochinchinensis.

作者信息

Shao Shun, Zhang Hao, Yuan Chun-Mao, Zhang Yu, Cao Ming-Ming, Zhang Hai-Yuan, Feng Yan, Ding Xiao, Zhou Qiang, Zhao Qing, He Hong-Ping, Hao Xiao-Jiang

机构信息

School of Pharmacy, Yunnan University of TCM, Kunming 650500, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.

出版信息

Phytochemistry. 2015 Aug;116:367-373. doi: 10.1016/j.phytochem.2015.02.028. Epub 2015 Mar 25.

DOI:10.1016/j.phytochem.2015.02.028

PMID:25817833

Abstract

Eight indole alkaloids, melosines A-H, together with 13 known alkaloids, were isolated from the fruits of Melodinus cochinchinensis. The structure elucidation of isolated secondary metabolites was based on comprehensive spectroscopic data analysis. Melosine B showed moderate cytotoxic activity against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7, and SW480 with IC50 values ranging from 1.6 to 8.1μM.

摘要

从越南酒饼叶的果实中分离出8种吲哚生物碱，即美乐新碱A - H，以及13种已知生物碱。通过综合光谱数据分析对分离得到的次生代谢产物进行结构解析。美乐新碱B对HL - 60、SMMC - 7721、A - 549、MCF - 7和SW480这5种人类癌细胞系显示出中等细胞毒性活性，IC50值在1.6至8.1μM之间。