The College of Public Health, Qingdao University, 38 Dengzhou Road, Qingdao 266021, China.
Nutrients. 2018 Mar 16;10(3):364. doi: 10.3390/nu10030364.
The associations between sarcopenia and metabolic syndrome (MetS) in non-obese middle-aged and older adults remain controversial. Thus, this meta-analysis aimed to evaluate the overall prevalence of MetS and the correlations between sarcopenia and MetS in middle-aged and older non-obese adults. We performed a systematic searched strategy using PUBMED, EMBASE and Web of Science databases for relevant observational studies investigating sarcopenia and MetS up to 11 May 2017. The polled prevalence of MetS and odds ratios with 95% confidence intervals (CI), as well as subgroup analyses were calculated using a random effects model. Twelve articles with a total of 35,581 participants were included. The overall prevalence of MetS was 36.45% (95% CI, 28.28-45.48%) in middle-aged and older non-obese adults with sarcopenia. Our analysis demonstrated a positive association between sarcopenia and MetS (OR = 2.01, 95% CI, 1.63-2.47). The subgroup analysis showed that both larger cohort size and the use of dual-energy X-ray absorptiometry to measure body composition can enhance the relationship. Our study revealed that a higher proportion of MetS in middle-aged and older non-obese people with sarcopenia. Moreover, sarcopenia was positively associated with MetS in this population. Further large-scale prospective cohort studies are needed to investigate the causality between sarcopenia and MetS.
非肥胖中老年人群中肌少症与代谢综合征（MetS）的相关性仍存在争议。因此，本荟萃分析旨在评估非肥胖中老年人群中 MetS 的总体患病率以及肌少症与 MetS 之间的相关性。我们使用 PUBMED、EMBASE 和 Web of Science 数据库进行了系统检索策略，以检索截至 2017 年 5 月 11 日调查肌少症和 MetS 的观察性研究。使用随机效应模型计算了 MetS 的流行率和 95%置信区间（CI）的比值比（OR），以及亚组分析。纳入了 12 篇文章，共 35581 名参与者。患有肌少症的非肥胖中老年人群中 MetS 的总体患病率为 36.45%（95%CI，28.28-45.48%）。我们的分析表明肌少症与 MetS 之间存在正相关（OR=2.01，95%CI，1.63-2.47）。亚组分析显示，较大的队列规模和使用双能 X 射线吸收法测量身体成分都可以增强这种关系。本研究表明，患有肌少症的非肥胖中老年人群中 MetS 的比例更高。此外，在该人群中，肌少症与 MetS 呈正相关。需要进一步的大规模前瞻性队列研究来探讨肌少症与 MetS 之间的因果关系。
