Department of Chemistry, Moravian College, Bethlehem, PA 18018, United States.
Curr Top Med Chem. 2018;18(7):611-624. doi: 10.2174/1568026618666180518095255.
Anomalous protein-protein interactions (PPIs) have been correlated to a variety of disease states, such as cancer, infectious disease, neurological disorders, diabetes, endocrine disorders and cardiovascular disease. Stapled peptides are an emerging intervention for these PPIs due to their improved structural rigidity and pharmacokinetic properties relative to unstapled peptides. This review details the most recent advances in the field of stapled peptide therapeutics, including the increasing variety of PPIs being targeted and types of peptide staples being employed.
异常的蛋白质-蛋白质相互作用 (PPIs) 与多种疾病状态相关，如癌症、传染病、神经紊乱、糖尿病、内分泌紊乱和心血管疾病。由于相对于非环肽具有改善的结构刚性和药代动力学特性，订书肽是这些 PPI 的新兴干预手段。本文详细介绍了订书肽治疗学领域的最新进展，包括越来越多的 PPI 靶点和肽订书钉类型的应用。
