Woolbright Benjamin L, Ayres Matthew, Taylor John A
Department of Urology, University of Kansas Medical Center, Kansas City, KS.
Department of Urology, University of Kansas Medical Center, Kansas City, KS.
Urol Oncol. 2018 Jul;36(7):327-337. doi: 10.1016/j.urolonc.2018.04.010.
Bladder cancer is a common solid tumor. Outcomes are poor in advanced disease, with few novel clinical therapeutics introduced over the previous several decades. Otto Warburg's original hypothesis that cancer cells use aerobic glycolysis to produce ATP instead of traditional oxidative phosphorylation in the mitochondria was a landmark discovery in its time. Recent studies indicate metabolic changes in cancer are far more complex than originally anticipated though. The purpose of this review is to understand metabolic changes that occur in bladder cancer, how targeting these changes could potentially be used therapeutically, and the current treatments that target these metabolic changes METHODS: A literature review on recent advances in cancer metabolism with an emphasis on bladder cancer was performed.
Significant metabolic change occurs in bladder cancer; however, these changes associated are not yet well understood. Therapeutic development in this area is growing and a diverse array of actionable targets such as mitochondrial DNA, mitochondrial metabolic enzymes and cellular signaling proteins have been identified. Many of these proteins may also be involved in chemoresistance.
Metabolism is a growing area of therapeutic interest in bladder cancer, but more studies are required to advance therapeutic development in this area.
膀胱癌是一种常见的实体瘤。晚期疾病的预后较差，在过去几十年里几乎没有新的临床治疗方法出现。奥托·瓦尔堡最初的假设，即癌细胞利用有氧糖酵解产生三磷酸腺苷（ATP），而非传统的线粒体氧化磷酸化，在当时是一项具有里程碑意义的发现。然而，最近的研究表明，癌症中的代谢变化远比最初预期的要复杂得多。本综述的目的是了解膀胱癌中发生的代谢变化、如何将针对这些变化的靶向治疗潜在地应用于临床治疗，以及目前针对这些代谢变化的治疗方法。方法：对癌症代谢的最新进展进行文献综述，重点关注膀胱癌。
膀胱癌中发生了显著的代谢变化；然而，这些相关变化尚未得到充分了解。该领域的治疗研究正在不断发展，已经确定了一系列可操作的靶点，如线粒体DNA、线粒体代谢酶和细胞信号蛋白。其中许多蛋白质可能也与化疗耐药性有关。
代谢是膀胱癌治疗中一个越来越受关注的领域，但需要更多的研究来推动该领域的治疗发展。
