Transcriptional activities of DUX4 fusions in B-cell acute lymphoblastic leukemia.
作者信息
Tanaka Yosuke, Kawazu Masahito, Yasuda Takahiko, Tamura Miki, Hayakawa Fumihiko, Kojima Shinya, Ueno Toshihide, Kiyoi Hitoshi, Naoe Tomoki, Mano Hiroyuki
机构信息
Department of Cellular Signaling, Graduate School of Medicine, The University of Tokyo.
Department of Medical Genomics, Graduate School of Medicine, The University of Tokyo
出版信息
Haematologica. 2018 Nov;103(11):e522-e526. doi: 10.3324/haematol.2017.183152. Epub 2018 May 17.
Abstract
摘要
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Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons.小鼠DUX和人类DUX4在激活卵裂期基因和MERVL/HERVL逆转录转座子中的保守作用。
Nat Genet. 2017 Jun;49(6):925-934. doi: 10.1038/ng.3844. Epub 2017 May 1.
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DUX-family transcription factors regulate zygotic genome activation in placental mammals.双盒家族转录因子调控胎盘哺乳动物的合子基因组激活。
Nat Genet. 2017 Jun;49(6):941-945. doi: 10.1038/ng.3858. Epub 2017 May 1.
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Conservation and innovation in the DUX4-family gene network.DUX4家族基因网络中的保守性与创新性。
Nat Genet. 2017 Jun;49(6):935-940. doi: 10.1038/ng.3846. Epub 2017 May 1.
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Deregulation of DUX4 and ERG in acute lymphoblastic leukemia.急性淋巴细胞白血病中DUX4和ERG的失调
Nat Genet. 2016 Dec;48(12):1481-1489. doi: 10.1038/ng.3691. Epub 2016 Oct 24.
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Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic Leukemia.成人及儿童B细胞急性淋巴细胞白血病的基因组分析
EBioMedicine. 2016 Jun;8:173-183. doi: 10.1016/j.ebiom.2016.04.038. Epub 2016 May 13.
6
Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia.在小儿 B 细胞前体急性淋巴细胞白血病中鉴定 ETV6-RUNX1 样和 DUX4 重排亚型。
Nat Commun. 2016 Jun 6;7:11790. doi: 10.1038/ncomms11790.
7
Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults.青少年和年轻成人 B 细胞急性淋巴细胞白血病中的复发性 DUX4 融合。
Nat Genet. 2016 May;48(5):569-74. doi: 10.1038/ng.3535. Epub 2016 Mar 28.
8
DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes.DUX4 通过其 C 末端招募 p300/CBP，并诱导整体 H3K27 乙酰化变化。
Nucleic Acids Res. 2016 Jun 20;44(11):5161-73. doi: 10.1093/nar/gkw141. Epub 2016 Mar 6.
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Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex.通过工程化的CRISPR-Cas9复合物进行全基因组规模的转录激活
Nature. 2015 Jan 29;517(7536):583-8. doi: 10.1038/nature14136. Epub 2014 Dec 10.
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