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The Role of Intercalated Cell in BP Regulation, Ion Transport, and Transporter Expression.
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Angiotensin II increases chloride absorption in the cortical collecting duct in mice through a pendrin-dependent mechanism.
Am J Physiol Renal Physiol. 2007 Mar;292(3):F914-20. doi: 10.1152/ajprenal.00361.2006. Epub 2006 Oct 31.
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Nitric oxide reduces Cl⁻ absorption in the mouse cortical collecting duct through an ENaC-dependent mechanism.
Am J Physiol Renal Physiol. 2013 Jun 1;304(11):F1390-7. doi: 10.1152/ajprenal.00292.2012. Epub 2013 Mar 20.
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Postnatal expression of transport proteins involved in acid-base transport in mouse kidney.
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Cortical distal nephron Cl(-) transport in volume homeostasis and blood pressure regulation.
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Reduced ENaC protein abundance contributes to the lower blood pressure observed in pendrin-null mice.
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α-Ketoglutarate stimulates pendrin-dependent Cl absorption in the mouse CCD through protein kinase C.
Am J Physiol Renal Physiol. 2018 Jul 1;315(1):F7-F15. doi: 10.1152/ajprenal.00576.2017. Epub 2018 Feb 7.

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Chloride/Multiple Anion Exchanger SLC26A Family: Systemic Roles of SLC26A4 in Various Organs.
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Novel functions of the anion exchanger AE4 (SLC4A9).
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Angiotensin II acts through Rac1 to upregulate pendrin: role of NADPH oxidase.
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The AE4 transporter mediates kidney acid-base sensing.
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Nedd4-2 up-regulation is associated with ACE2 ubiquitination in hypertension.
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Bicarbonate is the primary inducer of KCC3a expression in renal cortical B-type intercalated cells.
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Pendrin regulation is prioritized by anion in high-potassium diets.
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The proximal tubule through an NBCe1-dependent mechanism regulates collecting duct phenotypic and remodeling responses to acidosis.
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1
Dual regulation of the native ClC-K2 chloride channel in the distal nephron by voltage and pH.
J Gen Physiol. 2016 Sep;148(3):213-26. doi: 10.1085/jgp.201611623.
2
The ClC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron.
J Am Soc Nephrol. 2017 Jan;28(1):209-217. doi: 10.1681/ASN.2016010085. Epub 2016 Jun 22.
3
ENaC inhibition stimulates HCl secretion in the mouse cortical collecting duct. II. Bafilomycin-sensitive H+ secretion.
Am J Physiol Renal Physiol. 2015 Aug 1;309(3):F259-68. doi: 10.1152/ajprenal.00120.2015. Epub 2015 May 27.
4
Pendrin gene ablation alters ENaC subcellular distribution and open probability.
Am J Physiol Renal Physiol. 2015 Jul 15;309(2):F154-63. doi: 10.1152/ajprenal.00564.2014. Epub 2015 May 13.
5
ENaC inhibition stimulates HCl secretion in the mouse cortical collecting duct. I. Stilbene-sensitive Cl- secretion.
Am J Physiol Renal Physiol. 2015 Aug 1;309(3):F251-8. doi: 10.1152/ajprenal.00471.2013. Epub 2015 Apr 29.
6
Cortical distal nephron Cl(-) transport in volume homeostasis and blood pressure regulation.
Am J Physiol Renal Physiol. 2013 Aug 15;305(4):F427-38. doi: 10.1152/ajprenal.00022.2013. Epub 2013 May 1.
7
Renal intercalated cells are rather energized by a proton than a sodium pump.
Proc Natl Acad Sci U S A. 2013 May 7;110(19):7928-33. doi: 10.1073/pnas.1221496110. Epub 2013 Apr 22.
8
Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension.
J Clin Invest. 2013 Feb;123(2):657-65. doi: 10.1172/JCI61110. Epub 2013 Jan 25.
9
ENaC inhibition stimulates Cl- secretion in the mouse cortical collecting duct through an NKCC1-dependent mechanism.
Am J Physiol Renal Physiol. 2012 Jul 1;303(1):F45-55. doi: 10.1152/ajprenal.00030.2012. Epub 2012 Apr 11.
10
Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway.
J Am Soc Nephrol. 2011 Sep;22(9):1707-19. doi: 10.1681/ASN.2011020132. Epub 2011 Aug 18.

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