Maclean D, Mitchell E T, Wilcox R G, Walker P, Tyler H M
Department of Pharmacology and Clinical Pharmacology, Ninewells Hospital, Dundee, UK.
J Hum Hypertens. 1988 Aug;2(2):127-32.
The therapeutic usefulness of adding once-daily amlodipine (10 mg) for four weeks in moderate-severe hypertensive patients uncontrolled on low dose captopril (25 mg twice daily) alone was studied in 29 patients in a double-blind, placebo-controlled two-way crossover comparison. Once daily amlodipine was shown to be an effective antihypertensive drug when combined with captopril. The amlodipine minus placebo differences in mean changes from captopril baseline values were: -18/-12 mmHg and -20/-12 mmHg for supine and standing systolic/diastolic pressures (P less than 0.001 for all four pressure variables). The combination was well tolerated, and no patient discontinued therapy. Five patients experienced ankle oedema and four patients reported flushing while receiving amlodipine/captopril.
在一项双盲、安慰剂对照的双向交叉比较研究中，对29例单独使用低剂量卡托普利（每日2次，每次25mg）血压控制不佳的中重度高血压患者，加用一日一次氨氯地平（10mg）治疗四周的疗效进行了研究。结果显示，氨氯地平与卡托普利联合使用时是一种有效的降压药物。氨氯地平组与安慰剂组相比，收缩压和舒张压从卡托普利基线值的平均变化差值为：仰卧位收缩压/舒张压-18/-12mmHg，站立位收缩压/舒张压-20/-12mmHg（所有四个血压变量P均小于0.001）。该联合用药耐受性良好，无患者中断治疗。5例患者出现踝部水肿，4例患者在接受氨氯地平/卡托普利治疗时报告有面部潮红。
