tau 蛋白重复结构域的独特结构偏好。
The distinct structural preferences of tau protein repeat domains.
机构信息
Department of Physics, State Key Laboratory of Surface Physics, Key Laboratory for Computational Physical Science (Ministry of Education), Collaborative Innovation Center of Advanced Microstructures (Nanjing), Fudan University, Shanghai 200433, People's Republic of China.
出版信息
Chem Commun (Camb). 2018 May 31;54(45):5700-5703. doi: 10.1039/c8cc01263f.
Abstract
The tau fibrillar structures from the brain of an Alzheimer's patient have a core with a C-shaped motif of the third and fourth repeat domains (R3-R4). Our simulations indicated that the C-shaped motif is only stable for R3-R4, while R1-R2 tends to be linear in shape. These two structural motifs appear in the most stable K18 protofilament. Heparin can further stabilize the C-shaped R3-R4 motif, but not other repeats.
摘要
阿尔茨海默病患者大脑中的 tau 纤维结构具有核心，其第三和第四重复结构域（R3-R4）具有 C 形结构基序。我们的模拟表明，C 形基序仅在 R3-R4 中稳定，而 R1-R2 倾向于呈线性。这两种结构基序出现在最稳定的 K18 原纤维中。肝素可以进一步稳定 C 形的 R3-R4 基序，但不能稳定其他重复序列。
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