Center for Medical Genetics and Molecular Medicine , Haukeland University Hospital , 5021 Bergen , Norway.
J Proteome Res. 2018 Jul 6;17(7):2552-2555. doi: 10.1021/acs.jproteome.8b00175. Epub 2018 May 25.
Mass-spectrometry-based proteomics has become the standard approach for identifying and quantifying proteins. A vital step consists of analyzing experimentally generated mass spectra to identify the underlying peptide sequences for later mapping to the originating proteins. We here present the latest developments in SearchGUI, a common open-source interface for the most frequently used freely available proteomics search and de novo engines that has evolved into a central component in numerous bioinformatics workflows.
基于质谱的蛋白质组学已成为鉴定和定量蛋白质的标准方法。其中一个关键步骤是分析实验生成的质谱，以鉴定潜在的肽序列，以便以后映射到原始蛋白质。我们在此介绍 SearchGUI 的最新进展，它是最常用的免费蛋白质组学搜索和从头开始引擎的通用开源接口，现已发展成为许多生物信息学工作流程的核心组件。
