Department of Biochemistry and Molecular Biology, Army Medical University, Chongqing, 400038, People's Republic of China.
Center for Pharmacogenetics, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, USA.
J Neuroinflammation. 2018 May 17;15(1):146. doi: 10.1186/s12974-018-1173-x.
Our knowledge of the pathophysiology about traumatic brain injury (TBI) is still limited. Neutrophils, as the most abundant leukocytes in circulation and the first-line transmigrated immune cells at the sites of injury, are highly involved in the initiation, development, and recovery of TBI. Nonetheless, our understanding about neutrophils in TBI is obsolete, and mounting evidences from recent studies have challenged the conventional views. This review summarizes what is known about the relationships between neutrophils and pathophysiology of TBI. In addition, discussions are made on the complex roles as well as the controversial views of neutrophils in TBI.
我们对创伤性脑损伤 (TBI) 的病理生理学的了解仍然有限。中性粒细胞是循环中最丰富的白细胞，也是损伤部位第一时间迁移的免疫细胞，它们高度参与 TBI 的启动、发展和恢复。尽管如此，我们对 TBI 中性粒细胞的了解已经过时，最近的研究证据也对传统观点提出了挑战。本综述总结了目前已知的中性粒细胞与 TBI 病理生理学之间的关系。此外，还讨论了中性粒细胞在 TBI 中的复杂作用和有争议的观点。
