Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA
Vascular Biology Program and Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Development. 2018 May 18;145(16):dev156125. doi: 10.1242/dev.156125.
Although initially developed to replace animal testing in drug development, human 'organ on a chip' (organ chip) microfluidic culture technology offers a new tool for studying tissue development and pathophysiology, which has brought us one step closer to carrying out human experimentation In this Spotlight article, I discuss the central role that developmental biology played in the early stages of organ-chip technology, and how these models have led to new insights into human physiology and disease mechanisms. Advantages and disadvantages of the organ-chip approach relative to organoids and other human cell cultures are also discussed.
虽然最初是为了在药物开发中替代动物试验而开发的，但人类“芯片上器官”（器官芯片）微流控培养技术为研究组织发育和病理生理学提供了一种新工具，使我们更接近于进行人体试验。在这篇特写文章中，我讨论了发育生物学在器官芯片技术的早期阶段所起的核心作用，以及这些模型如何为人类生理学和疾病机制的新见解提供了帮助。还讨论了器官芯片方法相对于类器官和其他人类细胞培养物的优缺点。
