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组织芯片作为进展模型和刺激技术。

Tissue chips as headway model and incitement technology.

作者信息

Modi Prerna Suchitan, Singh Abhishek, Chaturvedi Awyang, Agarwal Shailly, Dutta Raghav, Nayak Ranu, Singh Alok Kumar

机构信息

Amity Institute of Biotechnology, Amity University Uttar Pradesh, Noida, Uttar Pradesh, India.

Amity Institute of Nanotechnology, Amity University Uttar Pradesh, Noida, Uttar Pradesh, India.

出版信息

Synth Syst Biotechnol. 2024 Aug 30;10(1):86-101. doi: 10.1016/j.synbio.2024.08.007. eCollection 2025.

DOI:10.1016/j.synbio.2024.08.007
PMID:39286054
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11403008/
Abstract

Tissue on a chip or organ-on-chip (OOC) is a technology that's dignified to form a transformation in drug discovery through the use of advanced platforms. These are 3D in cell culture models that mimic micro-environment of human organs or tissues on artificial microstructures built on a portable microfluidic chip without involving sacrificial humans or animals. This review article aims to offer readers a thorough and insightful understanding of technology. It begins with an in-depth understanding of chip design and instrumentation, underlining its pivotal role and the imperative need for its development in the modern scientific landscape. The review article explores into the myriad applications of OOC technology, showcasing its transformative impact on fields such as radiobiology, drug discovery and screening, and its pioneering use in space research. In addition to highlighting these diverse applications, the article provides a critical analysis of the current challenges that OOC technology faces. It examines both the biological and technical limitations that hinder its progress and efficacy and discusses the potential advancements and innovations that could drive the OOC technology forward. Through this comprehensive review, readers will gain a deep appreciation of the significance, capabilities, and evolving landscape of OOC technology.

摘要

芯片上的组织或器官芯片(OOC)是一项通过使用先进平台有望在药物发现领域引发变革的技术。这些是3D细胞培养模型,可在便携式微流控芯片上构建的人工微结构上模拟人体器官或组织的微环境,而无需使用人类或动物作为实验对象。这篇综述文章旨在让读者全面、深入地了解该技术。文章首先深入介绍芯片设计和仪器设备,强调其关键作用以及在现代科学领域发展的迫切需求。该综述文章探讨了器官芯片技术的众多应用,展示了其对放射生物学、药物发现与筛选等领域的变革性影响,以及在空间研究中的开创性应用。除了强调这些多样的应用,文章还对器官芯片技术目前面临的挑战进行了批判性分析。它审视了阻碍其发展和功效的生物学及技术限制,并讨论了可能推动器官芯片技术前进的潜在进展和创新。通过这一全面的综述,读者将深刻认识到器官芯片技术的重要性、能力以及不断发展的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e6b/11403008/3a8eb92b7bdf/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e6b/11403008/0a49705af98b/gr1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e6b/11403008/6d58723b68c3/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e6b/11403008/4dd238032fdc/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e6b/11403008/0a19436386b8/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e6b/11403008/d468b8f4be2f/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e6b/11403008/51891fdb3814/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e6b/11403008/3a8eb92b7bdf/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e6b/11403008/0a49705af98b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e6b/11403008/31a64c651ed4/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e6b/11403008/26fb0378d7e9/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e6b/11403008/6d58723b68c3/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e6b/11403008/4dd238032fdc/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e6b/11403008/0a19436386b8/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e6b/11403008/d468b8f4be2f/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e6b/11403008/51891fdb3814/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e6b/11403008/3a8eb92b7bdf/gr9.jpg

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本文引用的文献

1
Micro-Engineered Organoid-on-a-Chip Based on Mesenchymal Stromal Cells to Predict Immunotherapy Responses of HCC Patients.基于间充质基质细胞的微工程类器官芯片预测 HCC 患者的免疫治疗反应。
Adv Sci (Weinh). 2023 Sep;10(27):e2302640. doi: 10.1002/advs.202302640. Epub 2023 Jul 23.
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Patient-derived organoids of lung cancer based on organoids-on-a-chip: enhancing clinical and translational applications.基于芯片类器官的肺癌患者来源类器官:增强临床和转化应用。
Front Bioeng Biotechnol. 2023 May 26;11:1205157. doi: 10.3389/fbioe.2023.1205157. eCollection 2023.
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A Human Ovarian Tumor & Liver Organ-on-Chip for Simultaneous and More Predictive Toxo-Efficacy Assays.
用于同步和更具预测性的毒效分析的人卵巢肿瘤与肝脏芯片器官
Bioengineering (Basel). 2023 Feb 18;10(2):270. doi: 10.3390/bioengineering10020270.
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Integrating mechanical sensor readouts into organ-on-a-chip platforms.将机械传感器读数集成到芯片器官平台中。
Front Bioeng Biotechnol. 2022 Dec 16;10:1060895. doi: 10.3389/fbioe.2022.1060895. eCollection 2022.
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Small tissue chips with big opportunities for space medicine.小组织芯片为太空医学带来大机遇。
Life Sci Space Res (Amst). 2022 Nov;35:150-157. doi: 10.1016/j.lssr.2022.09.002. Epub 2022 Sep 8.
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Bioengineered Pancreas-Liver Crosstalk in a Microfluidic Coculture Chip Identifies Human Metabolic Response Signatures in Prediabetic Hyperglycemia.微流控共培养芯片中的生物工程胰腺-肝脏串扰鉴定出糖尿病前期高血糖症中人类代谢反应特征。
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Cells. 2022 Jun 2;11(11):1828. doi: 10.3390/cells11111828.
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