Department of Analytical Chemistry, Faculty of Chemistry, Gdańsk University of Technology, 11/12 Narutowicza Str., Gdańsk 80-233, Poland.
Department of Analytical Chemistry, Faculty of Chemistry, Gdańsk University of Technology, 11/12 Narutowicza Str., Gdańsk 80-233, Poland.
Environ Res. 2018 Aug;165:294-305. doi: 10.1016/j.envres.2018.05.004. Epub 2018 May 16.
The stability of the linings of packaging that is in contact with the goods stored has been of major concern during decades of the development of packaging materials. In this work, an attempt was undertaken to assess the applicability of using two bioassays (Microtox and XenoScreen YES/YAS) in estimating the stability of packaging (cans, caps, multilayer material) and the impact of their degradation on the toxicity of some simulated media. The assessment of the impact of packaging storage conditions (temperature, disinfection, preservation, extracting and washing solvents) was planned and performed with i) regression modeling of the experimental effects on the ecotoxicity readings, ii) ANOVA and MANOVA estimation of the experimental conditions as significant factors affecting the toxicity results and iii) FTIR analysis of the packages. It is shown that the effects of temperature and extraction solvents could be quantitatively assessed by the agreement between all methods applied. It can be stated that temperature and acidity as well as the alcohol content in the sensitive media have the greatest impact on the toxicity of the extract and thus on the stability of the internal lining and the extractability of xenobiotics.
几十年来，包装材料不断发展，包装与储存货物直接接触的衬里的稳定性一直是人们关注的主要问题。在这项工作中，我们尝试使用两种生物测定法（Microtox 和 XenoScreen YES/YAS）来评估包装（罐、盖、多层材料）的稳定性及其降解对一些模拟介质毒性的影响。计划并进行了包装储存条件（温度、消毒、保存、提取和洗涤溶剂）的影响评估，方法是：i）用实验对生态毒性读数的影响进行回归建模，ii）用方差分析和多变量分析评估作为影响毒性结果的重要因素的实验条件，以及 iii）对包装进行傅里叶变换红外（FTIR）分析。结果表明，所有应用方法之间的一致性可以定量评估温度和提取溶剂的影响。可以说，温度和酸度以及敏感介质中的酒精含量对提取物的毒性以及内部衬里的稳定性和异生素的提取性有最大的影响。
