了解并解决男男性行为人群中丙型肝炎病毒再感染问题。
Understanding and Addressing Hepatitis C Virus Reinfection Among Men Who Have Sex with Men.
机构信息
Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, 9500 Gilman Drive La Jolla, CA 92093-0507, USA.
Institute for Infectious Diseases, University of Bern, Bern, Switzerland, Friedbühlstrasse 53, Personalhaus 6, 3010 Bern, Switzerland.
出版信息
Infect Dis Clin North Am. 2018 Jun;32(2):395-405. doi: 10.1016/j.idc.2018.02.004.
Abstract
Hepatitis C virus reinfection rates among men who have sex with men are high. Factors associated with infection point to varied sexual and drug-related risks that could be targeted for interventions to prevent infection/reinfection. Modeling indicates that tackling increasing incidence and high reinfection rates requires high levels of hepatitis C virus treatment combined with behavioral interventions. Enhanced testing strategies and prompt retreating of reinfection may be required to promptly diagnosed reinfections. Behavioral interventions studies addressing reinfection are required. Other interventions include traditional harm reduction interventions, adapted behavioral interventions, and interventions to prevent harms related to ChemSex and other risk factors.
摘要
男男性行为者中的丙型肝炎病毒再感染率很高。与感染相关的因素表明存在不同的性和与药物相关的风险，这些风险可以作为预防感染/再感染的干预措施的目标。建模表明，要解决发病率上升和高再感染率的问题，需要高水平的丙型肝炎病毒治疗与行为干预相结合。需要增强检测策略和及时对再感染进行治疗，以迅速诊断再感染。需要进行针对再感染的行为干预研究。其他干预措施包括传统的减少伤害干预、适应性行为干预以及预防 ChemSex 和其他风险因素相关危害的干预。
相似文献
1
Understanding and Addressing Hepatitis C Virus Reinfection Among Men Who Have Sex with Men.了解并解决男男性行为人群中丙型肝炎病毒再感染问题。
Infect Dis Clin North Am. 2018 Jun;32(2):395-405. doi: 10.1016/j.idc.2018.02.004.
2
Strategies to Reduce Hepatitis C Virus Reinfection in People Who Inject Drugs.减少注射吸毒者中丙型肝炎病毒再感染的策略。
Infect Dis Clin North Am. 2018 Jun;32(2):371-393. doi: 10.1016/j.idc.2018.02.003.
3
Low hepatitis C virus reinfection rate despite ongoing risk following universal access to direct-acting antiviral therapy among people living with HIV.尽管在艾滋病毒感染者中普遍获得直接作用抗病毒治疗后仍存在持续的风险，但丙型肝炎病毒再感染率较低。
AIDS. 2020 Jul 15;34(9):1347-1358. doi: 10.1097/QAD.0000000000002562.
4
HCV reinfection incidence and spontaneous clearance rates in HIV-positive men who have sex with men in Western Europe.在西欧 HIV 阳性男男性行为者中 HCV 再感染发生率和自发清除率。
J Hepatol. 2017 Feb;66(2):282-287. doi: 10.1016/j.jhep.2016.09.004. Epub 2016 Sep 17.
5
Reinfection With the Hepatitis C Virus in Men Who Have Sex With Men After Successful Treatment With Direct-acting Antivirals in Germany: Current Incidence Rates, Compared With Rates During the Interferon Era.德国经直接作用抗病毒药物治疗后成功的男男性行为者中丙型肝炎病毒再感染：当前的发病率与干扰素时代的发病率比较。
Clin Infect Dis. 2020 Aug 22;71(5):1248-1254. doi: 10.1093/cid/ciz949.
6
HCV reinfection rates after cure or spontaneous clearance among HIV-infected and uninfected men who have sex with men.HIV 感染者和非 HIV 感染者男男性行为者治愈或自发清除 HCV 后的再感染率。
Liver Int. 2021 Mar;41(3):482-493. doi: 10.1111/liv.14762. Epub 2020 Dec 22.
7
Incidence of HCV Reinfection Among HIV-Positive MSM and Its Association With Sexual Risk Behavior: A Longitudinal Analysis.HIV 阳性男男性行为者中 HCV 再感染的发生率及其与性行为风险的关系：一项纵向分析。
Clin Infect Dis. 2021 Aug 2;73(3):460-467. doi: 10.1093/cid/ciaa645.
8
Incidence, risk factors, and prevention of hepatitis C reinfection: a population-based cohort study.丙型肝炎再感染的发生率、危险因素和预防：一项基于人群的队列研究。
Lancet Gastroenterol Hepatol. 2017 Mar;2(3):200-210. doi: 10.1016/S2468-1253(16)30182-0. Epub 2016 Dec 23.
9
HCV Cure and Reinfection Among People With HIV/HCV Coinfection and People Who Inject Drugs.HIV/HCV合并感染及注射吸毒者中的丙型肝炎病毒治愈与再感染
Curr HIV/AIDS Rep. 2017 Jun;14(3):110-121. doi: 10.1007/s11904-017-0358-8.
10
HCV reinfections after viral clearance among HIV-positive patients with recent HCV infection in Taiwan.台湾地区近期 HCV 感染的 HIV 阳性患者中病毒清除后的 HCV 再感染。
Liver Int. 2019 Oct;39(10):1860-1867. doi: 10.1111/liv.14199. Epub 2019 Aug 5.
引用本文的文献
1
Expanding hepatitis C virus test uptake using self-testing among men who have sex with men in China: two parallel randomized controlled trials.在中国男男性行为者中使用自我检测扩大丙型肝炎病毒检测：两项平行随机对照试验。
BMC Med. 2023 Jul 28;21(1):279. doi: 10.1186/s12916-023-02981-w.
2
The experienced positive and negative influence of HIV on quality of life of people with HIV and vulnerable to HIV in the Netherlands.荷兰艾滋病毒感染者和艾滋病毒脆弱人群生活质量的经验性艾滋病毒正负面影响。
Sci Rep. 2022 Dec 19;12(1):21887. doi: 10.1038/s41598-022-25113-5.
3
Hepatitis C microelimination among people living with HIV in Taiwan.台湾地区 HIV 感染者中丙型肝炎的消除
Emerg Microbes Infect. 2022 Dec;11(1):1664-1671. doi: 10.1080/22221751.2022.2081620.
4
Sexually-transmitted hepatitis C virus reinfections among people living with HIV in Taiwan: the emerging role of genotype 6.台湾地区 HIV 感染者中新发的性传播丙型肝炎病毒感染：基因型 6 的新作用。
Emerg Microbes Infect. 2022 Dec;11(1):1227-1235. doi: 10.1080/22221751.2022.2065933.
5
The perceived impact of an HIV cure by people living with HIV and key populations vulnerable to HIV in the Netherlands: A qualitative study.荷兰艾滋病毒感染者及易感染艾滋病毒的关键人群对治愈艾滋病毒的认知影响：一项定性研究。
J Virus Erad. 2022 Feb 25;8(1):100066. doi: 10.1016/j.jve.2022.100066. eCollection 2022 Mar.
本文引用的文献
1
Trends in HCV treatment uptake, efficacy and impact on liver fibrosis in the Swiss HIV Cohort Study.瑞士艾滋病毒队列研究中 HCV 治疗接受率、疗效及对肝纤维化影响的趋势。
Liver Int. 2018 Mar;38(3):424-431. doi: 10.1111/liv.13528. Epub 2017 Aug 23.
2
On the potential of a short-term intensive intervention to interrupt HCV transmission in HIV-positive men who have sex with men: A mathematical modelling study.关于短期强化干预对中断男男性行为艾滋病毒感染者丙型肝炎病毒传播的潜力：一项数学建模研究。
J Viral Hepat. 2018 Jan;25(1):10-18. doi: 10.1111/jvh.12752. Epub 2017 Aug 23.
3
Treatment and primary prevention in people who inject drugs for chronic hepatitis C infection: is elimination possible in a high-prevalence setting?注射毒品者慢性丙型肝炎感染的治疗与一级预防：在高流行环境中能否实现消除？
Addiction. 2017 Jul;112(7):1290-1299. doi: 10.1111/add.13764. Epub 2017 Feb 17.
4
HCV reinfection incidence and spontaneous clearance rates in HIV-positive men who have sex with men in Western Europe.在西欧 HIV 阳性男男性行为者中 HCV 再感染发生率和自发清除率。
J Hepatol. 2017 Feb;66(2):282-287. doi: 10.1016/j.jhep.2016.09.004. Epub 2016 Sep 17.
5
Hepatitis C virus transmission among human immunodeficiency virus-infected men who have sex with men: Modeling the effect of behavioral and treatment interventions.丙型肝炎病毒在感染人类免疫缺陷病毒的男男性行为者中的传播：行为和治疗干预效果的建模
Hepatology. 2016 Dec;64(6):1856-1869. doi: 10.1002/hep.28769. Epub 2016 Oct 19.
6
Management of Hepatitis C/HIV Coinfection in the Era of Highly Effective Hepatitis C Virus Direct-Acting Antiviral Therapy.高效丙型肝炎病毒直接抗病毒治疗时代的丙型肝炎/艾滋病病毒合并感染管理
Clin Infect Dis. 2016 Jul 15;63 Suppl 1(Suppl 1):S3-S11. doi: 10.1093/cid/ciw219.
7
Prices, Costs, and Affordability of New Medicines for Hepatitis C in 30 Countries: An Economic Analysis.30个国家丙型肝炎新药的价格、成本及可负担性：一项经济分析
PLoS Med. 2016 May 31;13(5):e1002032. doi: 10.1371/journal.pmed.1002032. eCollection 2016 May.
8
Treatment scale-up to achieve global HCV incidence and mortality elimination targets: a cost-effectiveness model.实现全球 HCV 发病率和死亡率消除目标的治疗扩大化：成本效益模型。
Gut. 2017 Aug;66(8):1507-1515. doi: 10.1136/gutjnl-2016-311504. Epub 2016 Apr 12.
9
Chemsex and the city: sexualised substance use in gay bisexual and other men who have sex with men attending sexual health clinics.《化学性爱与城市：在性健康诊所就诊的男同性恋、双性恋及其他与男性发生性行为的男性中的性化物质使用情况》
Int J STD AIDS. 2017 Mar;28(4):362-366. doi: 10.1177/0956462416651229. Epub 2016 Jul 10.
10
Effectiveness of needle/syringe programmes and opiate substitution therapy in preventing HCV transmission among people who inject drugs.针头/注射器项目及阿片类药物替代疗法在预防注射吸毒者丙型肝炎病毒传播方面的有效性。
Cochrane Database Syst Rev. 2016;2016(1). doi: 10.1002/14651858.CD012021. Epub 2016 Jan 12.
Zotero 插件