KU Leuven, Department of Development and Regeneration, Organ Systems, Leuven, Belgium; Department of Obstetrics and Gynaecology, Leuven University Fertility Centre, University Hospital Leuven, Leuven, Belgium.
Department of Basic Sciences, Ponce Health Sciences University - School of Medicine & Ponce Research Institute, Ponce, PR, USA; Department of Ob-Gyn, Ponce Health Sciences University - School of Medicine & Ponce Research Institute, Ponce, PR, USA.
Best Pract Res Clin Obstet Gynaecol. 2018 Jul;50:72-83. doi: 10.1016/j.bpobgyn.2018.04.001. Epub 2018 Apr 13.
A noninvasive biomarker-based test could help shorten the diagnostic delay for endometriosis. The most investigated biomarker sources are peripheral blood and endometrium. Discovery of endometriosis biomarkers is often hypothesis-driven, i.e. when one or a few biomarkers are investigated based on their role in the disease pathogenesis. Alternatively, a hypothesis-generating approach has been followed using the "omics" technologies. A variety of biomarkers for endometriosis have been investigated, but no biomarker has been validated for clinical use. Many challenges lie ahead in the endometriosis biomarker field. In the future, harmonized collection and reporting methods should allow large-scale international collaboration for highly powered studies.
一种基于非侵入性生物标志物的检测方法可能有助于缩短子宫内膜异位症的诊断延迟。最受研究的生物标志物来源是外周血和子宫内膜。子宫内膜异位症生物标志物的发现通常是基于假说的，即根据其在疾病发病机制中的作用来研究一个或几个生物标志物。或者，也可以使用“组学”技术采用生成假说的方法。已经研究了多种用于子宫内膜异位症的生物标志物，但没有一种生物标志物已被验证可用于临床应用。子宫内膜异位症生物标志物领域还面临许多挑战。将来，应通过协调采集和报告方法来实现大规模的国际合作，以开展更具影响力的研究。
