Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, People's Republic of China.
Department of Pharmacy, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, Hubei Province, People's Republic of China.
Fitoterapia. 2018 Jul;128:79-85. doi: 10.1016/j.fitote.2018.05.006. Epub 2018 May 17.
Three new cleistanthane diterpenoids, phyllanglins A-C (1-3), a new natural product, 4-acetyl-bergenin (4), and three known compounds (5-7) were isolated from the roots of Phyllanthus glaucus. Their structures were elucidated by extensive spectroscopic data analyses and single-crystal X-ray diffraction. Phyllanglins A-C were unusual cleistanthane diterpenoids with phenylacetylene moieties, and a plausible biogenetic pathway was proposed to discuss the origins of them. All of the isolates were evaluated for their anti-inflammatory activities.
从叶下珠 Phyllanthus glaucus 的根部分离得到三个新的 Cleistanthane 二萜类化合物， Phyllanglins A-C（1-3），一个新的天然产物 4-乙酰- Bergenin（4）和三个已知化合物（5-7）。通过广泛的光谱数据分析和单晶 X 射线衍射确定了它们的结构。Phyllanglins A-C 是具有苯乙炔部分的不寻常的 Cleistanthane 二萜类化合物，提出了一个合理的生物发生途径来讨论它们的起源。对所有分离物进行了抗炎活性评估。
