State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
Fitoterapia. 2018 Mar;125:89-93. doi: 10.1016/j.fitote.2017.12.005. Epub 2017 Dec 27.
Four new cleistanthane diterpenoids, phyllaciduloids A-D (1-4), were isolated from the roots and stems of Phyllanthus acidus (L.) Skeels (Phyllanthaceae). Their structures were elucidated on the basis of extensive spectroscopic analysis. Phyllaciduloids B-D (2-4) present in their structures with ether bond between C-7 and C-16, which were rarely reported. All the isolates were evaluated for their cytotoxic activities against five human cancer cell lines.
从 Phyllanthus acidus (L.) Skeels（藤黄科）的根和茎中分离得到了四个新的 Cleistanthane 二萜类化合物，即 phyllaciduloids A-D（1-4）。基于广泛的光谱分析确定了它们的结构。phyllaciduloids B-D（2-4）在结构中存在 C-7 和 C-16 之间的醚键，这很少有报道。对所有分离物进行了抗五种人癌细胞系的细胞毒性活性评价。
