State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
University of Chinese Academy of Sciences, Beijing, People's Republic of China.
Nat Prod Res. 2022 Oct;36(20):5241-5246. doi: 10.1080/14786419.2021.1929971. Epub 2021 Jun 2.
Phyllaciduloids E () and F (), two new cleistanthane diterpenoids, were isolated from the leaves of (L.) Skeels (Phyllanthaceae). Their planar structures were established by spectroscopic analysis and comparison with literature values. The relative configurations of phyllaciduloids E and F were confirmed by DFT-NMR chemical shift calculations and subsequent CP3 probability methods. Phyllaciduloids E and F were evaluated for their cytotoxicity. However, no significant activities were detected at concentrations up to 40 μM.[Formula: see text].
从叶（）（藤黄科）中分离得到两个新的克拉烷二萜 Phyllaciduloids E() 和 F()。通过光谱分析和与文献值比较确定了它们的平面结构。通过 DFT-NMR 化学位移计算和随后的 CP3 概率方法确定了 Phyllaciduloids E 和 F 的相对构型。评估了 Phyllaciduloids E 和 F 的细胞毒性。然而，在高达 40 μM 的浓度下，没有检测到显著的活性。[化学式：见正文]。
