思考大脑胰岛素抵抗。
Thinking about brain insulin resistance.
作者信息
Al Haj Ahmad Reem M, Al-Domi Hayder A
机构信息
Department of Nutrition and Food Technology, Faculty of Agriculture, The University of Jordan, Queen Rania Street, Amman 11942, Jordan.
Department of Nutrition and Food Technology, Faculty of Agriculture, The University of Jordan, Queen Rania Street, Amman 11942, Jordan.
出版信息
Diabetes Metab Syndr. 2018 Nov;12(6):1091-1094. doi: 10.1016/j.dsx.2018.05.003. Epub 2018 May 6.
INTRODUCTION
Dementia and type 2 diabetes mellitus (T2DM) are two of the epidemics of our time; in which insulin resistance (IR) is playing the central role. Epidemiological studies found that different types of dementia development may be promoted by the presence of T2DM.
OBJECTIVES
We aimed in this review to highlight the role of insulin and the IR in the brain as a pathophysiological factor of dementia development and also to expand our understanding of T2DM as a mediator of IR in the brain and to review the possible mechanisms of action that may explain the association.
METHODOLOGY
A critical review of the relevant published English articles up to 2018, using PubMed, Google Scholar, Science Direct, ADI, and WHO database was carried out. Keywords were included insulin resistance, T3DM, T2DM, dementia, brain insulin resistance were used.
CONCLUSION
The rapidly increased prevalence of dementia concurrently with T2DM and obesity need urgent action to illustrate guidelines for prevention, modifying, and treatment based on mechanistic studies.
引言
痴呆症和2型糖尿病（T2DM）是当今的两大流行病，胰岛素抵抗（IR）在其中起着核心作用。流行病学研究发现，T2DM的存在可能会促进不同类型痴呆症的发展。
目的
在本综述中，我们旨在强调胰岛素和IR在大脑中作为痴呆症发展的病理生理因素所起的作用，同时扩展我们对T2DM作为大脑中IR介导因素的理解，并回顾可能解释这种关联的作用机制。
方法
使用PubMed、谷歌学术、科学Direct、ADI和世界卫生组织数据库，对截至2018年已发表的相关英文文章进行了批判性综述。使用的关键词包括胰岛素抵抗、T3DM、T2DM、痴呆症、大脑胰岛素抵抗。
结论
痴呆症患病率与T2DM和肥胖症同时迅速上升，需要采取紧急行动，根据机制研究制定预防、改善和治疗指南。
Zotero 插件