用于抗体片段细胞内递送的营养与代谢治疗优化

MNT Optimization for Intracellular Delivery of Antibody Fragments.

作者信息

Ulasov A V, Khramtsov Y V, Lupanova T N, Tsvetkova A D, Rosenkranz A A, Slastnikova T A, Georgiev G P, Sobolev A S

机构信息

Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia.

Faculty of Biology, Moscow State University, Moscow, 119992, Russia.

出版信息

Dokl Biochem Biophys. 2018 Mar;479(1):62-65. doi: 10.1134/S1607672918020023. Epub 2018 May 19.

DOI:10.1134/S1607672918020023

PMID:29779097

Abstract

We studied the possibility of optimizing modular nanotransporters (MNTs) for the intracellular delivery of antibody fragments into the nuclei of cells of a specified type. Basic MNT with a reduced size retaining the desired functions was obtained, and the principal possibility of obtaining an MNT carrying an antibody fragment by microbiological synthesis was shown.

摘要

我们研究了优化模块化纳米转运体（MNTs）以将抗体片段细胞内递送至特定类型细胞核的可能性。获得了尺寸减小但仍保留所需功能的基础MNT，并展示了通过微生物合成获得携带抗体片段的MNT的主要可能性。