用于抗体片段细胞内递送的营养与代谢治疗优化
MNT Optimization for Intracellular Delivery of Antibody Fragments.
作者信息
Ulasov A V, Khramtsov Y V, Lupanova T N, Tsvetkova A D, Rosenkranz A A, Slastnikova T A, Georgiev G P, Sobolev A S
机构信息
Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia.
Faculty of Biology, Moscow State University, Moscow, 119992, Russia.
出版信息
Dokl Biochem Biophys. 2018 Mar;479(1):62-65. doi: 10.1134/S1607672918020023. Epub 2018 May 19.
We studied the possibility of optimizing modular nanotransporters (MNTs) for the intracellular delivery of antibody fragments into the nuclei of cells of a specified type. Basic MNT with a reduced size retaining the desired functions was obtained, and the principal possibility of obtaining an MNT carrying an antibody fragment by microbiological synthesis was shown.
我们研究了优化模块化纳米转运体（MNTs）以将抗体片段细胞内递送至特定类型细胞核的可能性。获得了尺寸减小但仍保留所需功能的基础MNT，并展示了通过微生物合成获得携带抗体片段的MNT的主要可能性。
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