染色质重塑复合体亚基的稳定性由其磷酸化状态决定。
Stability of Chromatin Remodeling Complex Subunits Is Determined by Their Phosphorylation Status.
作者信息
Azieva A M, Sheinov A A, Galkin F A, Georgieva S G, Soshnikova N V
机构信息
Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia.
Kurchatov Institute National Research Center, Moscow, 123182, Russia.
出版信息
Dokl Biochem Biophys. 2018 Mar;479(1):66-68. doi: 10.1134/S1607672918020035. Epub 2018 May 19.
It was found that, in the differentiated cells of mouse brain, the level of core (Brg1 and BAF155) and specific (BRD7, BAF180, and PHF10) subunits of the chromatin-remodeling complex PBAF is reduced compared to the undifferentiated proliferating cells. Phosphorylation of PBAF complex subunits is required for maintaining their stability in differentiated brain cells.
研究发现，与未分化的增殖细胞相比，在小鼠脑的分化细胞中，染色质重塑复合物PBAF的核心（Brg1和BAF155）及特异性（BRD7、BAF180和PHF10）亚基水平降低。PBAF复合物亚基的磷酸化是维持其在分化脑细胞中稳定性所必需的。
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