Vuong Celine K, Black Douglas L, Zheng Sika
Molecular Biology Interdepartmental Graduate Program, University of California at Los Angeles, Los Angeles, California 90095, USA.
Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California 90095, USA.
Nat Rev Neurosci. 2016 May;17(5):265-81. doi: 10.1038/nrn.2016.27.
Alternative precursor-mRNA splicing is a key mechanism for regulating gene expression in mammals and is controlled by specialized RNA-binding proteins. The misregulation of splicing is implicated in multiple neurological disorders. We describe recent mouse genetic studies of alternative splicing that reveal its critical role in both neuronal development and the function of mature neurons. We discuss the challenges in understanding the extensive genetic programmes controlled by proteins that regulate splicing, both during development and in the adult brain.
可变前体mRNA剪接是哺乳动物中调节基因表达的关键机制，由专门的RNA结合蛋白控制。剪接失调与多种神经疾病有关。我们描述了最近关于可变剪接的小鼠遗传学研究，这些研究揭示了其在神经元发育和成熟神经元功能中的关键作用。我们讨论了在理解由调节剪接的蛋白质所控制的广泛遗传程序时所面临的挑战，这些程序在发育过程中和成体大脑中均存在。
