Đukanović Ljubica, Račić Maja, Marić Ivko, Maksimović Zlatko, Simić Jelena, Aleksić Jela, Stanković Sanja, Pejović Vesna, Ležaić Višnja
School of Medicine, University of Belgrade, Belgrade, Serbia.
Faculty of Medicine Foča, University of East Sarajevo, Foča, Bosnia and Herzegovina.
Int Urol Nephrol. 2018 Jul;50(7):1301-1309. doi: 10.1007/s11255-018-1889-7. Epub 2018 May 19.
In the early 1970s, a number of authors described the development of Balkan endemic nephropathy (BEN) in immigrants in endemic regions. The aim of this study was to examine whether immigrants in endemic regions are suffering from BEN today.
The study involved 193 residents of two endemic regions divided into three groups: two groups of native residents-(1) members of BEN families, (2) members of non-BEN families, and (3) immigrants, who had moved from non-affected settlements to the endemic regions of Kolubara (38 years ago) or Semberia (20 years ago). All persons were subjected to an interview, objective examination, kidney ultrasound, and laboratory analysis to detect the presence of BEN consensus diagnostic criteria.
The number of immigrants with BEN biomarkers outside cutoff values was significantly lower than for BEN family members. Five BEN family members met diagnostic criteria for BEN and four for suspected BEN. Although five non-BEN family members had different combinations of BEN biomarkers, all of them had diseases other than BEN in which these biomarkers also occurred. None of the immigrants met the criteria for BEN. Nevertheless, one descendant of an immigrant, a 78-year-old male, whose mother was from a non-BEN family in the Kolubara district, exhibited all the criteria for BEN: alpha1-microglobulinuria, chronic renal failure, and anemia.
While 30 years ago, BEN was reported equally among immigrants and natives, currently it is diagnosed in some BEN family members in the eighth decade of life, but extremely rarely in immigrants also in old age.
20世纪70年代初，一些作者描述了流行地区移民中巴尔干地方性肾病（BEN）的发展情况。本研究的目的是调查如今流行地区的移民是否患有BEN。
该研究涉及两个流行地区的193名居民，分为三组：两组本地居民——（1）BEN家族成员，（2）非BEN家族成员，以及（3）移民，他们分别于38年前从非疫区迁至科卢巴拉流行区，或于20年前迁至森贝里亚流行区。所有人员均接受访谈、客观检查、肾脏超声检查和实验室分析，以检测是否存在BEN共识诊断标准。
生物标志物超出临界值的移民数量明显低于BEN家族成员。五名BEN家族成员符合BEN诊断标准，四名符合疑似BEN诊断标准。尽管五名非BEN家族成员有不同组合的BEN生物标志物，但他们都患有除BEN之外的疾病，这些生物标志物也在这些疾病中出现。没有移民符合BEN标准。然而，一名移民的后代，一名78岁男性（其母亲来自科卢巴拉地区的非BEN家族），表现出了所有BEN标准：α1-微球蛋白尿、慢性肾衰竭和贫血。
虽然30年前，移民和本地人中BEN的报告率相同，但目前在80岁左右的一些BEN家族成员中被诊断出患有BEN，但在老年移民中极为罕见。
