Seo Hyeonglim, Choi Ikjang, Whiting Nicholas, Hu Jingzhe, Luu Quy Son, Pudakalakatti Shivanand, McCowan Caitlin, Kim Yaewon, Zacharias Niki, Lee Seunghyun, Bhattacharya Pratip, Lee Youngbok
Department of Bionano Technology, Hanyang University, Ansan, 15588, South Korea.
Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Chemphyschem. 2018 Sep 5;19(17):2143-2147. doi: 10.1002/cphc.201800461. Epub 2018 Jun 13.
Porous silicon nanoparticles have recently garnered attention as potentially-promising biomedical platforms for drug delivery and medical diagnostics. Here, we demonstrate porous silicon nanoparticles as contrast agents for Si magnetic resonance imaging. Size-controlled porous silicon nanoparticles were synthesized by magnesiothermic reduction of silica nanoparticles and were surface activated for further functionalization. Particles were hyperpolarized via dynamic nuclear polarization to enhance their Si MR signals; the particles demonstrated long Si spin-lattice relaxation (T ) times (∼25 mins), which suggests potential applicability for medical imaging. Furthermore, Si hyperpolarization levels were sufficient to allow Si MRI in phantoms. These results underscore the potential of porous silicon nanoparticles that, when combined with hyperpolarized magnetic resonance imaging, can be a powerful theragnostic deep tissue imaging platform to interrogate various biomolecular processes in vivo.
多孔硅纳米颗粒最近作为药物递送和医学诊断的潜在有前景的生物医学平台而受到关注。在此，我们展示了多孔硅纳米颗粒作为硅磁共振成像的造影剂。通过二氧化硅纳米颗粒的镁热还原合成了尺寸可控的多孔硅纳米颗粒，并对其表面进行活化以进行进一步功能化。颗粒通过动态核极化进行超极化以增强其硅磁共振信号；这些颗粒表现出较长的硅自旋 - 晶格弛豫（T）时间（约25分钟），这表明其在医学成像方面具有潜在的适用性。此外，硅超极化水平足以在体模中进行硅磁共振成像。这些结果强调了多孔硅纳米颗粒的潜力，当与超极化磁共振成像相结合时，它可以成为一个强大的治疗诊断深部组织成像平台，用于在体内探究各种生物分子过程。
