Johnson-Lynn Sarah, Cooney Alan, Ferguson Diarmaid, Bunn Deborah, Gray William, Coorsh Jonathan, Kakwani Rajesh, Townshend David
Trauma and Orthopaedics, North Tyneside General Hospital, Tyne and Wear, UK.
Foot Ankle Spec. 2019 Apr;12(2):153-158. doi: 10.1177/1938640018776065. Epub 2018 May 21.
Platelet-rich plasma (PRP) has been advocated for treatment of plantar fasciitis but there are few good-quality clinical trials to support its use. We conducted a feasibility study of PRP versus saline for treatment of plantar fasciitis. Patients with 6 months or more of magnetic resonance imaging-proven plantar fasciitis, who had failed conservative treatment were invited to participate in the study. Patients were block randomized to either PRP or an equivalent volume of saline. The techniques used for injection and rehabilitation were standardized for both groups. The patient and assessor were blinded. Visual analogue scale (VAS) for pain and painDETECT score were recorded preoperatively and at 6 months follow-up. From 35 patients approached, 28 (19 female, mean age 50 years) were recruited, with 14 randomized to each arm. At 6 months, 8 patients (28.6%) were lost to follow-up. There was a significant change in VAS score from baseline to follow-up in both intervention (mean change 37.2, P = .008) and control (mean change 42.2, P = .003) groups. There was no correlation between preoperative painDETECT score and change in VAS. Recruitment and loss to follow-up rates were relatively high. Both treatments resulted in a similar, significant, improvement in symptoms. Levels of Evidence: Level II.
富血小板血浆（PRP）已被提倡用于治疗足底筋膜炎，但支持其使用的高质量临床试验较少。我们进行了一项关于PRP与生理盐水治疗足底筋膜炎的可行性研究。邀请经磁共振成像证实患有足底筋膜炎6个月或更长时间且保守治疗失败的患者参与研究。患者被整群随机分为PRP组或等量生理盐水组。两组的注射和康复技术均标准化。患者和评估者均不知情。术前及随访6个月时记录疼痛视觉模拟量表（VAS）评分和疼痛DETECT评分。在35名被邀请的患者中，招募了28名（19名女性，平均年龄50岁），每组随机分配14名。6个月时，8名患者（28.6%）失访。干预组（平均变化37.2，P = .008）和对照组（平均变化42.2，P = .003）从基线到随访时VAS评分均有显著变化。术前疼痛DETECT评分与VAS变化之间无相关性。招募率和失访率相对较高。两种治疗均使症状得到了类似的显著改善。证据级别：II级。
