1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine , Seoul, Republic of Korea.
2 Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine , Seoul, Republic of Korea.
Thyroid. 2018 Jul;28(7):849-856. doi: 10.1089/thy.2017.0656. Epub 2018 Jun 15.
Lipid profiles of men and women change differently during the aging process. Guidelines recommend that dyslipidemia patients should consider screening for hypothyroidism without consideration of age or sex.
Data from the sixth Korean National Health and Nutrition Examination Survey were used. A total of 4275 participants without thyroid disease and without a past history of dyslipidemia or dyslipidemia medication were evaluated. The association between thyroid dysfunction and lipid profiles (total cholesterol [TC], low-density lipoprotein cholesterol [LDLC], and triglycerides [TG]) was analyzed by age and sex.
The prevalence of thyroid dysfunction was significantly different according to TC and LDLC levels (p = 0.003 and p = 0.021, respectively). In women, the weighted prevalence of thyroid dysfunction was significantly different according to levels of TC, LDLC, and TG (p = 0.007, p = 0.016, and p = 0.044, respectively). However, in men, no association was found in any of the lipid profiles. Female participants were divided into two groups using a cutoff age of 55 years. In younger women, the weighted prevalence of thyroid dysfunction was different according to the levels of TC, LDLC, and TG (p = 0.013, p = 0.007, and p = 0.007, respectively). However, in older women, no association was found for any of the lipid profiles.
The prevalence of thyroid dysfunction was significantly different according to lipid profiles, and this association differed by age and sex.
男性和女性的脂质谱在衰老过程中变化不同。指南建议，血脂异常患者应考虑筛查甲状腺功能减退症，而不考虑年龄或性别。
使用第六届韩国国家健康和营养检查调查的数据。共评估了 4275 名无甲状腺疾病且无血脂异常或血脂异常药物治疗史的参与者。根据年龄和性别分析甲状腺功能障碍与血脂谱（总胆固醇[TC]、低密度脂蛋白胆固醇[LDLC]和甘油三酯[TG]）之间的关系。
甲状腺功能障碍的患病率根据 TC 和 LDLC 水平显著不同（p=0.003 和 p=0.021）。在女性中，TC、LDLC 和 TG 水平的甲状腺功能障碍的加权患病率显著不同（p=0.007、p=0.016 和 p=0.044）。然而，在男性中，任何血脂谱均无关联。使用 55 岁的截定点将女性参与者分为两组。在较年轻的女性中，TC、LDLC 和 TG 水平的甲状腺功能障碍的加权患病率不同（p=0.013、p=0.007 和 p=0.007）。然而，在较年长的女性中，任何血脂谱均无关联。
甲状腺功能障碍的患病率根据脂质谱显著不同，这种关联因年龄和性别而异。
