用于诊断结核感染的全血γ-干扰素释放试验（QuantiFERON-TB Gold In-Tube）检测性能的季节性变化。
Seasonal variation in the performance of QuantiFERON-TB Gold In-Tube assays used for the diagnosis of tuberculosis infection.
作者信息
Tebruegge Marc, Curtis Nigel, Clifford Vanessa, Fernandez-Turienzo Cristina, Klein Nigel, Fidler Katy, Mansour Salah, Elkington Paul, Morris-Jones Stephen
机构信息
Academic Unit of Clinical and Experimental Sciences Faculty of Medicine & Global Health Research Institute, University of Southampton, Tremona Road, Southampton, UK; UCL Great Ormond Street Institute of Child Health, University College London, 30 Guildford Street, London, UK; Department of Paediatric Infectious Diseases & Immunology, Evelina London Children's Hospital, Guy's and St. Thomas' NHS Foundation Trust, Lambeth Palace Road, London, UK; Department of Paediatrics, The University of Melbourne, Flemington Road, Parkville, Australia.
Department of Paediatrics, The University of Melbourne, Flemington Road, Parkville, Australia; Murdoch Children's Research Institute, Royal Children's Hospital Melbourne, Flemington Road, Parkville, Australia.
出版信息
Tuberculosis (Edinb). 2018 May;110:26-29. doi: 10.1016/j.tube.2018.03.002. Epub 2018 Mar 8.
This study aimed to determine whether there are seasonal changes in the performance of QuantiFERON-TB Gold In-Tube (QFT-GIT) assays, an interferon-gamma release assay widely used for the diagnosis of tuberculosis infection. Results of 31,932 QFT-GIT assays performed at a large independent, accredited diagnostic service provider in London, UK over a 4.5-year-period were analysed. The proportion of positive results was significantly lower in autumn (14.8%) than in spring (16.0%; p = 0.0366) and summer (17.5%; p < 0.0001), but similar to winter (15.2%; p = 0.4711). The proportion of indeterminate results was significantly higher in autumn (8.2%) than in spring (6.2%; p < 0.0001), summer (4.8%; p < 0.0001), and winter (6.2%; p < 0.0001). The highest proportions of indeterminate results were observed in October (8.4%) and November (8.8%), the lowest in June (4.5%). Our data show that significant seasonal variation occurs in the performance of QFT-GIT assays in a temperate climate setting. Potential underlying mechanisms, including host and environmental factors, are discussed.
本研究旨在确定用于诊断结核感染的广泛使用的干扰素-γ释放试验——管内QuantiFERON-TB Gold（QFT-GIT）检测的性能是否存在季节性变化。分析了在英国伦敦一家大型独立的、经认可的诊断服务提供商在4.5年期间进行的31932次QFT-GIT检测结果。秋季阳性结果的比例（14.8%）显著低于春季（16.0%；p = 0.0366）和夏季（17.5%；p < 0.0001），但与冬季（15.2%；p = 0.4711）相似。秋季不确定结果的比例（8.2%）显著高于春季（6.2%；p < 0.0001）、夏季（4.8%；p < 0.0001）和冬季（6.2%；p < 0.0001）。不确定结果比例最高出现在10月（8.4%）和11月（8.8%），最低出现在6月（4.5%）。我们的数据表明，在温带气候环境中，QFT-GIT检测的性能存在显著的季节性变化。文中讨论了包括宿主和环境因素在内的潜在潜在机制。
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