School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA; Malaria Host-Pathogen Interaction Center, Emory University, Atlanta, GA 30322, USA.
School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA; Malaria Host-Pathogen Interaction Center, Emory University, Atlanta, GA 30322, USA.
Trends Parasitol. 2018 Jul;34(7):617-632. doi: 10.1016/j.pt.2018.04.003. Epub 2018 May 18.
Malaria is a serious, complex disease caused by parasites of the genus Plasmodium. Plasmodium parasites affect multiple tissues as they evade immune responses, replicate, sexually reproduce, and transmit between vertebrate and invertebrate hosts. The explosion of omics technologies has enabled large-scale collection of Plasmodium infection data, revealing systems-scale patterns, mechanisms of pathogenesis, and the ways that host and pathogen affect each other. Here, we provide an overview of recent efforts using systems biology approaches to study host-Plasmodium interactions and the biological themes that have emerged from these efforts. We discuss some of the challenges in using systems biology for this goal, key research efforts needed to address those issues, and promising future malaria applications of systems biology.
疟疾是一种由疟原虫属寄生虫引起的严重、复杂的疾病。疟原虫寄生虫在逃避免疫反应、复制、有性繁殖和在脊椎动物和无脊椎动物宿主之间传播时，会影响多种组织。组学技术的爆炸式发展使得大规模收集疟原虫感染数据成为可能，揭示了系统规模的模式、发病机制的机制以及宿主和病原体相互影响的方式。在这里，我们提供了一个使用系统生物学方法研究宿主-疟原虫相互作用和从这些努力中出现的生物学主题的最新进展概述。我们讨论了使用系统生物学实现这一目标所面临的一些挑战、解决这些问题所需的关键研究努力以及系统生物学在未来疟疾应用方面的前景。
