INSERM UMR906, GIMP, Labex ParaFrap.
Malaria Research and Training Center, Department of Epidemiology of Parasitic Disease, Faculty of Medicine, USTTB.
J Infect Dis. 2017 Sep 15;216(6):771-775. doi: 10.1093/infdis/jix359.
Cerebral malaria, a reversible encephalopathy affecting young children, is a medical emergency requiring urgent clinical assessment and treatment. We performed a whole-transcriptomic analysis of blood samples from Malian children with cerebral or uncomplicated malaria. We focused on transcripts from pathways for which dysfunction has been associated with neurodegenerative disorders. We found that SNCA, SIAH2, UBB, HSPA1A, TUBB2A, and PINK1 were upregulated (fold-increases, ≥2.6), whereas UBD and PSMC5 were downregulated (fold-decreases, ≤4.39) in children with cerebral malaria, compared with those with uncomplicated malaria. These findings provide the first evidence for pathogenic mechanisms common to human cerebral malaria and neurodegenerative disorders.
脑型疟疾是一种影响幼儿的可逆性脑病，属于医疗急症，需要进行紧急临床评估和治疗。我们对马里患有脑型疟疾或无并发症疟疾的儿童的血液样本进行了全转录组分析。我们重点研究了与神经退行性疾病相关功能障碍的通路中的转录本。与无并发症疟疾患儿相比，我们发现脑型疟疾患儿的 SNCA、SIAH2、UBB、HSPA1A、TUBB2A 和 PINK1 的表达上调（倍数变化，≥2.6），而 UBD 和 PSMC5 的表达下调（倍数变化，≤4.39）。这些发现为人类脑型疟疾和神经退行性疾病的共同致病机制提供了首个证据。
