Aix Marseille University, CNRS, IMM, LCB, 13009 Marseille, France.
Aix Marseille University, CNRS, IMM, LCB, 13009 Marseille, France.
Biochim Biophys Acta Gene Regul Mech. 2019 Jul;1862(7):691-696. doi: 10.1016/j.bbagrm.2018.05.003. Epub 2018 May 19.
The symbiotic nitrogen fixing species Sinorhizobium meliloti represents a remarkable model system for the class Alphaproteobacteria, which includes genera such as Caulobacter, Agrobacterium and Brucella. It is capable of living free in the soil, and is also able to establish a complex symbiosis with leguminous plants, during which its cell cycle program is completely rewired presumably due, at least in part, to the action of peptides secreted by the plant. Here we will discuss how the cell cycle regulation works in S. meliloti and the kinds of molecular mechanisms that take place during the infection. We will focus on the complex regulation of the master regulator of the S. meliloti cell cycle, the response regulator CtrA, discussing its implication in symbiosis.
共生固氮物种根瘤农杆菌代表了α变形菌纲的一个显著模式系统，该纲包括根瘤菌属、土壤杆菌属和布鲁氏菌属等属。它能够在土壤中自由生活，也能够与豆科植物建立复杂的共生关系，在此过程中，其细胞周期程序可能会被完全重新布线，这至少部分归因于植物分泌的肽的作用。在这里，我们将讨论细胞周期调控在 S. meliloti 中的作用，以及感染过程中发生的各种分子机制。我们将重点讨论 S. meliloti 细胞周期的主调控因子应答调节子 CtrA 的复杂调控，讨论其在共生中的意义。
