Department of Clinical Laboratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
Department of Clinical Laboratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Antimicrob Agents Chemother. 2018 Jul 27;62(8). doi: 10.1128/AAC.00701-18. Print 2018 Aug.
A multidrug-resistant (MDR) strain was isolated in 2006 from a urine sample. The isolate harbored the gene, which was located in a chromosomal Tn-like class 3 integron as a gene cassette array of Two mutations in and one mutation in were detected in quinolone-resistance-determining regions (QRDRs). We report a full-length, novel, -carrying class 3 integron. This integron, together with mutations in QRDRs, could have influenced the MDR phenotype.
2006 年，从一份尿液样本中分离出一株耐多药（MDR）菌株。该分离株携带基因，该基因位于染色体 Tn 样类 3 整合子中，作为基因盒阵列。在喹诺酮耐药决定区（QRDRs）中检测到和中的两个突变和中的一个突变。我们报告了一个全长的、新型的携带类 3 整合子的基因。该整合子与 QRDRs 中的突变一起可能影响了 MDR 表型。
