Division of Birth Cohort Study, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, Guangzhou, China.
Institute of Applied Health Research, University of Birmingham, Birmingham, UK.
Obes Rev. 2018 Sep;19(9):1256-1268. doi: 10.1111/obr.12693. Epub 2018 May 21.
Low and high birthweight is known to increase the risk of acute and longer-term adverse outcomes, such as stillbirth, infant mortality, obesity, type 2 diabetes and cardiovascular diseases. Gestational dyslipidaemia is associated with a numbers of adverse birth outcomes, but evidence regarding birthweight is still inconsistent to reliably inform clinical practice and treatment recommendations.
The aim of this study was to explore the relationship between maternal gestational dyslipidaemia and neonatal health outcomes, namely, birthweight, metabolic factors and inflammatory parameters.
We searched systematically Embase, MEDLINE, PubMed, CINAHL Plus and Cochrane Library up to 1 August 2016 (with an updated search in MEDLINE at the end of July 2017) for longitudinal studies that assessed the association of maternal lipid levels during pregnancy with neonatal birthweight, or metabolic and inflammatory parameters up to 3 years old.
Data from 46 publications including 31,402 pregnancies suggest that maternal high triglycerides and low high-density-lipoprotein cholesterol levels throughout pregnancy are associated with increased birthweight, higher risk of large for gestational age and macrosomia and lower risk of small-for-gestational age. The findings were consistent across the studied populations, but stronger associations were observed in women who were overweight or obese prior to pregnancy.
This meta-analysis suggested that the potential under-recognized adverse effects of intrauterine exposure to maternal dyslipidaemia may warrant further investigation into the relationship between maternal dyslipidaemia and birthweight in large prospective cohorts or in randomized trials.
低出生体重和高出生体重已知会增加急性和长期不良后果的风险，例如死产、婴儿死亡率、肥胖、2 型糖尿病和心血管疾病。妊娠血脂异常与许多不良出生结局有关，但关于出生体重的证据仍然不一致，无法可靠地为临床实践和治疗建议提供信息。
本研究旨在探讨母体妊娠血脂异常与新生儿健康结局（即出生体重、代谢因素和炎症参数）之间的关系。
我们系统地检索了 Embase、MEDLINE、PubMed、CINAHL Plus 和 Cochrane Library，截至 2016 年 8 月 1 日（2017 年 7 月底在 MEDLINE 进行了更新搜索），以寻找评估母亲在怀孕期间血脂水平与新生儿出生体重或代谢和炎症参数之间关系的纵向研究，随访时间长达 3 年。
来自 46 篇文献的数据包括 31402 例妊娠表明，整个孕期母体高甘油三酯和低高密度脂蛋白胆固醇水平与出生体重增加、巨大儿和巨大儿风险增加以及小于胎龄儿风险降低有关。这些发现与研究人群一致，但在怀孕前超重或肥胖的女性中观察到更强的关联。
这项荟萃分析表明，子宫内暴露于母体血脂异常的潜在未被认识到的不良影响可能需要进一步研究母体血脂异常与出生体重之间的关系，在大型前瞻性队列或随机试验中进行研究。
