Mu Fangxiang, Wang Weijing, Liu Lin, Hu Ning, Wang Fang
Department of Reproductive Medicine, Lanzhou University Second Hospital, Lanzhou, China.
Front Nutr. 2024 Aug 29;11:1439599. doi: 10.3389/fnut.2024.1439599. eCollection 2024.
This research aims to investigate the impact of omega-3 fatty acids supplementation on the lipid levels of pregnant women who have experienced pregnancy losses.
This retrospective study analyzed data from pregnant women with previous pregnancy losses from two medical centers. Their lipid profiles were measured at least twice during pregnancy. According to the use of omega-3 soft gel capsules, participants were divided into the omega-3 group and the control group. We assessed the relationship between omega-3 fatty acids supplementation and longitudinal lipid levels during pregnancy using generalized estimating equations (GEE). Subsequently, we conducted subgroup analyses to delineate the profile of beneficiaries who received omega-3 fatty acids based on body mass index (BMI), age, menstrual regularity, number of previous pregnancy losses, number of previous live births, and educational level.
The omega-3 group included 105 participants, while the control group comprised 274 participants. Women in the omega-3 group started supplementation between 3.43 and 17.14 weeks of gestation. According to GEE analysis, supplementing omega-3 fatty acids significantly reduced triglyceride (TG) levels during pregnancy (adjusted β = -0.300, 95% CI -0.445 to -0.154, < 0.001). No associations between omega-3 fatty acids supplementation and total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), or high-density lipoprotein cholesterol (HDL-C) levels were observed. Subgroup analyses revealed that omega-3 fatty acids supplementation was related to a reduction in TG levels among pregnant women with age of ≤35 years, a normal BMI (18.5-24.9 kg/m), 1-2 previous pregnancy losses, no previous live births, or an educational level above high school.
Supplementation with omega-3 fatty acids may significantly reduce TG levels, yet it does not seem to improve TC, LDL-C, or HDL-C levels in pregnant women with previous pregnancy losses.
本研究旨在探讨补充ω-3脂肪酸对有过流产史孕妇血脂水平的影响。
这项回顾性研究分析了来自两个医疗中心有过流产史孕妇的数据。在孕期至少对她们的血脂水平进行了两次测量。根据是否使用ω-3软胶囊，将参与者分为ω-3组和对照组。我们使用广义估计方程（GEE）评估孕期补充ω-3脂肪酸与纵向血脂水平之间的关系。随后，我们进行亚组分析，以根据体重指数（BMI）、年龄、月经规律、既往流产次数、既往活产次数和教育水平来描绘接受ω-3脂肪酸的受益人群特征。
ω-3组包括105名参与者，而对照组有274名参与者。ω-3组的女性在妊娠3.43至17.14周之间开始补充。根据GEE分析，补充ω-3脂肪酸在孕期显著降低了甘油三酯（TG）水平（校正β=-0.300，95%CI -0.445至-0.154，P<0.001）。未观察到补充ω-3脂肪酸与总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）或高密度脂蛋白胆固醇（HDL-C）水平之间存在关联。亚组分析显示，补充ω-3脂肪酸与年龄≤35岁、BMI正常（18.5-24.9kg/m²）、既往有1-2次流产、无既往活产或教育水平高于高中的孕妇TG水平降低有关。
补充ω-3脂肪酸可能显著降低TG水平，但似乎并不能改善有过流产史孕妇的TC、LDL-C或HDL-C水平。
