Ryznychuk Mariana O, Kryvchanska Mariana I, Lastivka Irina V, Bulyk Roman Ye
Pediatrics And Medical Genetics Department, Higher State Educational Establishment Of Ukraine "Bukovinian State Medical University", Chernivtsi, Ukraine.
Medical Biology And Genetics Department, Higher State Educational Establishment Of Ukraine "Bukovinian State Medical University", Chernivtsi, Ukraine.
Wiad Lek. 2018;71(2 pt 2):339-344.
Introduction: The pathogenesis of spina bifida depends on time, region, race and ethnicity. It is found in 4.7 per 10.000 of live born children worldwide. The aim: The incidence in children of Northern Bukovina was analyzed. The spina bifida incidence for 2007-2016 in this region, as well as, compared to some countries according to EUROCAT data was studied.
Materials and methods: A retrospective study to analyze the risk factors for spina bifida was carried out. A case-control study was conducted using clinical records of 34 children with this pathology (16 boys and 18 girls) aged 0-18 years living in Northern Bukovina. 44 case records of healthy children (26 boys and 18 girls) were compared.
Results: According to EUROCAT, the prevalence of spina bifida in the studied countries varied in the range of 0.13-0.50‰. The spina bifida incidence in Northern Bukovina (0.22 ‰) does not exceed the statistics for Ukraine (0.29 ‰) throughout the study period.
Conclusions: This study provides a comprehension overview of a number of factors determining spina bifida risks: third pregnancy, miscarriage, high emotional stress during pregnancy, TORCH infection in pregnant, poor housing, maternal age, co-habiting, residence near contaminated lands, hard physical work preconceptionally, smoking habits, military service, etc. The most probable spina bifida preventive factors in children are: high school education of parents and using folic acid during the first trimester of pregnancy. Nevertheless, our data present new factual material, which requires further in-depth study, it is already clear that all the above indicators are associated with increased risk for spina bifida-complicated pregnancies.
