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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Parkes D G, Coghlan J P, McDougall J G, Scoggins B A

Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1988 Jan;15(1):67-70. doi: 10.1111/j.1440-1681.1988.tb01009.x.

Haemodynamic effects of 20 micrograms and 100 micrograms injection of atrial natriuretic factor 99-126 (ANF) were studied in conscious sheep. 2. ANF injection rapidly decreased blood pressure associated with a fall in total peripheral resistance, increased heart rate and cardiac output. These parameters returned to normal within 5 min of injection. 3. This study shows that ANF has an initial vasodilatory action to decrease blood pressure, which is different from the hypotensive mechanism seen with short-term infusion (60 min) of ANF in sheep.

在清醒绵羊中研究了注射20微克和100微克心房利钠因子99 - 126（ANF）的血流动力学效应。2. 注射ANF后血压迅速下降，同时总外周阻力降低，心率和心输出量增加。这些参数在注射后5分钟内恢复正常。3. 本研究表明，ANF具有初始血管舒张作用以降低血压，这与在绵羊中短期输注（60分钟）ANF时所见的降压机制不同。

Parkes D G, Coghlan J P, McDougall J G, Scoggins B A

Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1988 Jan;15(1):67-70. doi: 10.1111/j.1440-1681.1988.tb01009.x.

Haemodynamic effects of 20 micrograms and 100 micrograms injection of atrial natriuretic factor 99-126 (ANF) were studied in conscious sheep. 2. ANF injection rapidly decreased blood pressure associated with a fall in total peripheral resistance, increased heart rate and cardiac output. These parameters returned to normal within 5 min of injection. 3. This study shows that ANF has an initial vasodilatory action to decrease blood pressure, which is different from the hypotensive mechanism seen with short-term infusion (60 min) of ANF in sheep.

在清醒绵羊中研究了注射20微克和100微克心房利钠因子99 - 126（ANF）的血流动力学效应。2. 注射ANF后血压迅速下降，同时总外周阻力降低，心率和心输出量增加。这些参数在注射后5分钟内恢复正常。3. 本研究表明，ANF具有初始血管舒张作用以降低血压，这与在绵羊中短期输注（60分钟）ANF时所见的降压机制不同。