电路布线：神经突速配与稳定的突触匹配。
Circuit Wiring: Neurite Speed Dating versus Stable Synaptic Matchmaking.
机构信息
Department of Neuroscience, Columbia University Medical Center, New York, NY 10027, USA; Mortimer B. Zuckerman Mind Brain Behavior Institute, New York, NY, USA.
Department of Neuroscience, Columbia University Medical Center, New York, NY 10027, USA; Mortimer B. Zuckerman Mind Brain Behavior Institute, New York, NY, USA; Kavli Institute for Brain Sciences, Columbia University Medical Center, New York, NY 10027, USA.
出版信息
Dev Cell. 2018 May 21;45(4):423-424. doi: 10.1016/j.devcel.2018.05.008.
Abstract
Understanding the mechanisms establishing the complex but precise pattern of connectivity characterizing neural circuits remains an immense challenge. In a recent issue of Neuron, Mao and colleagues (2018) provide new insights by showing that the activation kinetics of EphB2, a transmembrane receptor tyrosine kinase, control whether dendritic filopodia makes a synapse with candidate axons.
摘要
理解建立神经回路复杂而精确连接模式的机制仍然是一个巨大的挑战。在最近一期的《神经元》杂志上，Mao 和他的同事（2018）提供了新的见解，表明跨膜受体酪氨酸激酶 EphB2 的激活动力学控制着树突丝状伪足是否与候选轴突形成突触。
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