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肺神经内分泌细胞:肺部的传感器和哨兵。

Pulmonary Neuroendocrine Cells: Sensors and Sentinels of the Lung.

机构信息

Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.

Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA; Duke Cancer Institute, Duke University Medical Center, Durham, NC 27710, USA; Regeneration Next, Duke University, Durham, NC 27710, USA.

出版信息

Dev Cell. 2018 May 21;45(4):425-426. doi: 10.1016/j.devcel.2018.05.009.

Abstract

Organisms have developed cellular "antennas" to sense, interpret, and integrate environmental stimuli. In a recent issue of Science, Sui et al. (2018) demonstrate that discrete clusters of pulmonary neuroendocrine cells in the lung can sense airborne allergens and relay signals to stimulate immune cells and induce tissue/organ-wide responses.

摘要

生物已经进化出细胞“天线”来感知、解释和整合环境刺激。在最近一期的《科学》杂志上,Sui 等人(2018)表明,肺部离散的神经内分泌细胞簇可以感知空气中的过敏原,并传递信号来刺激免疫细胞,诱导组织/器官范围的反应。

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