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应激诱导糖皮质激素释放在创伤后应激障碍发生中的致病作用：一项实验研究

Pathogenetic Role of the Stress-induced Release of Glucocorticoid Hormones in the Development of Post-traumatic Stress Disorder: An Experimental Study.

作者信息

Zenko M Y, Baranova K A, Rybnikova E A

机构信息

Pavlov Institute of Physiology, Russian Academy of Sciences, St.-Petersburg, Russia.

出版信息

Dokl Biol Sci. 2018 Mar;479(1):51-53. doi: 10.1134/S0012496618020059. Epub 2018 May 22.

DOI:10.1134/S0012496618020059
PMID:29790026
Abstract

In the rat experimental model of posttraumatic stress disorder (PTSD), the level of blood corticosterone was at least eight-fold increased (an overrelease). The use of hypobaric hypoxic preconditioning or short-term inhibition of glucocorticoid synthesis by metyrapone injection prevented development of the experimental PTSD.

摘要

在创伤后应激障碍（PTSD）大鼠实验模型中，血液皮质酮水平至少增加了八倍（过度释放）。使用低压缺氧预处理或通过注射甲吡酮短期抑制糖皮质激素合成可预防实验性PTSD的发生。

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Pathogenetic Role of the Stress-induced Release of Glucocorticoid Hormones in the Development of Post-traumatic Stress Disorder: An Experimental Study.应激诱导糖皮质激素释放在创伤后应激障碍发生中的致病作用：一项实验研究
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Can posttraumatic stress disorder be prevented with glucocorticoids?糖皮质激素能否预防创伤后应激障碍？
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Pathophysiology. 2024 Dec 6;31(4):709-760. doi: 10.3390/pathophysiology31040051.
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Catecholamines in Post-traumatic Stress Disorder: A Systematic Review and Meta-Analysis.创伤后应激障碍中的儿茶酚胺：系统评价与荟萃分析
Front Mol Neurosci. 2018 Dec 4;11:450. doi: 10.3389/fnmol.2018.00450. eCollection 2018.

本文引用的文献

1
Inhibiting corticosterone synthesis during fear memory formation exacerbates cued fear extinction memory deficits within the single prolonged stress model.在单次长时间应激模型中，恐惧记忆形成过程中抑制皮质酮合成会加剧线索性恐惧消退记忆缺陷。
Behav Brain Res. 2015;287:182-6. doi: 10.1016/j.bbr.2015.03.043. Epub 2015 Mar 31.
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Stable modifications to the expression of neurohormones in the rat hypothalamus in a model of post-traumatic stress disorder.创伤后应激障碍模型中大鼠下丘脑神经激素表达的稳定变化。
Neurosci Behav Physiol. 2010 Jan;40(1):111-5. doi: 10.1007/s11055-009-9216-5. Epub 2009 Dec 11.
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创伤后应激障碍中抗抑郁药的药理学替代方案：一项系统综述
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Cortisol and post-traumatic stress disorder in adults: systematic review and meta-analysis.成人中的皮质醇与创伤后应激障碍：系统评价与荟萃分析
Br J Psychiatry. 2007 Nov;191:387-92. doi: 10.1192/bjp.bp.106.024877.
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Dose-dependent suppression of adrenocortical activity with metyrapone: effects on emotion and memory.美替拉酮对肾上腺皮质活动的剂量依赖性抑制：对情绪和记忆的影响。
Psychoneuroendocrinology. 1996 Nov;21(8):681-93. doi: 10.1016/s0306-4530(96)00028-5.
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Hypothalamic-pituitary-adrenal dysfunction in posttraumatic stress disorder.创伤后应激障碍中的下丘脑 - 垂体 - 肾上腺功能障碍。
Biol Psychiatry. 1991 Nov 15;30(10):1031-48. doi: 10.1016/0006-3223(91)90123-4.