Division of Rheumatology, Department of Internal Medicine, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Republic of Korea.
Department of Family Medicine, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Republic of Korea.
Clin Rheumatol. 2018 Sep;37(9):2529-2538. doi: 10.1007/s10067-018-4130-2. Epub 2018 May 23.
Hyperuricemia is not only a risk factor for gout but also an independent determinant of hypertension, diabetes, and chronic kidney diseases. Although the incidence of gout in Korean adults is increasing, epidemiologic studies on hyperuricemia in the general Korean population are limited. Thus, this study aimed at evaluating the prevalence of hyperuricemia and its associated factors among non-institutionalized Korean adults. The present study included 5548 participants (2403 men and 3145 women) aged ≥ 19 years from The Korea National Health and Nutrition Examination Survey. Based on the new 2016 census data, the age-standardized prevalence and mean uric acid level were calculated using the chi-square test and t test, respectively. A multivariate logistic regression analysis was performed to evaluate the risk factors associated with hyperuricemia. The age-standardized prevalence of hyperuricemia and mean uric acid level in the general Korean population was 11.4% (17.0% in men and 5.9% in women) and 5.1 mg/dL (5.83 mg/dL in men and 4.36 mg/dL in women), respectively. The prevalence of hyperuricemia was high in young Korean adults, and a U-shaped association was observed between hyperuricemia and age. While obesity, metabolic syndrome, renal impairment, and low-grade inflammation were positively associated with hyperuricemia in both sexes, alcohol consumption, education, and current smoking status had a positive association with hyperuricemia only in women. Hyperuricemia is prevalent in the young population in Korea, and special efforts are necessary to reduce the potential harmful effects of hyperuricemia on the health of adults, particularly the younger-generation adults, in Korea.
高尿酸血症不仅是痛风的危险因素，也是高血压、糖尿病和慢性肾脏病的独立决定因素。尽管韩国成年人痛风的发病率正在增加，但针对普通韩国人群高尿酸血症的流行病学研究有限。因此，本研究旨在评估非住院韩国成年人高尿酸血症的患病率及其相关因素。本研究纳入了来自韩国国家健康与营养调查的 5548 名年龄≥19 岁的参与者（2403 名男性和 3145 名女性）。基于 2016 年新的人口普查数据，使用卡方检验和 t 检验分别计算年龄标准化患病率和平均尿酸水平。采用多变量 logistic 回归分析评估与高尿酸血症相关的危险因素。韩国普通人群的高尿酸血症年龄标准化患病率和平均尿酸水平分别为 11.4%（男性 17.0%，女性 5.9%）和 5.1mg/dL（男性 5.83mg/dL，女性 4.36mg/dL）。韩国年轻成年人的高尿酸血症患病率较高，且高尿酸血症与年龄之间呈 U 型关联。肥胖、代谢综合征、肾功能损害和低度炎症在男女两性中均与高尿酸血症呈正相关，而饮酒、教育程度和当前吸烟状况仅与女性的高尿酸血症呈正相关。高尿酸血症在韩国年轻人群中较为普遍，需要特别努力降低高尿酸血症对韩国成年人健康的潜在有害影响，特别是年轻一代成年人。
