Huang Dongni, Ma Jing, Zhao Yan, Pan Qi, Xu Guogang, Guo Lixin
Department of Endocrinology, Beijing Hospital, National Center for Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Front Endocrinol (Lausanne). 2025 Jun 27;16:1619370. doi: 10.3389/fendo.2025.1619370. eCollection 2025.
The ratio of C-reactive protein to high-density lipoprotein cholesterol (CRP/HDL-c) reflects systemic inflammation and lipid status, both of which are implicated in uric acid metabolism. This study aimed to investigate the association between CRP/HDL-c and the prevalence of hyperuricemia (HUA) among adults with diabetes or prediabetes.
This cross-sectional study included 10915 adults with diabetes or prediabetes from the Health Management Institute of the PLA General Hospital. Hyperuricemia was defined as a serum uric acid concentration ≥7 mg/dL in men and ≥6 mg/dL in women. Participants were divided into quartiles according to the ratio. Multivariate logistic regression and restricted cubic spline analyses were used to assess associations. Subgroup analyses and interaction tests were performed.
The prevalence of HUA increased across CRP/HDL-c quartiles (18.43%, 20.39%, 24.54%, and 29.82%; P < 0.001). Higher CRP/HDL-c levels were independently associated with increased HUA risk (odds ratio [OR] = 1.64, 95% confidence interval [CI]: 1.14-2.36; = 0.008). Participants in the highest quartile had a significantly higher risk compared to those in the lowest quartile (OR = 1.33, 95% CI: 1.15-1.54; < 0.001). The association was stronger in females (OR = 1.30) than in males (OR = 1.14), with a significant gender interaction ( for interaction = 0.031). Among females, the association was more pronounced in those aged <50 years (OR = 1.47). RCS analysis indicated a linear dose-response relationship.
An elevated C-reactive protein to high-density lipoprotein cholesterol ratio is significantly associated with a higher risk of hyperuricemia in adults with diabetes or prediabetes, particularly in younger females.
C反应蛋白与高密度脂蛋白胆固醇的比值（CRP/HDL-c）反映全身炎症和脂质状态，二者均与尿酸代谢有关。本研究旨在探讨CRP/HDL-c与糖尿病或糖尿病前期成年人高尿酸血症（HUA）患病率之间的关联。
这项横断面研究纳入了来自中国人民解放军总医院健康管理研究院的10915名糖尿病或糖尿病前期成年人。高尿酸血症定义为男性血清尿酸浓度≥7mg/dL，女性≥6mg/dL。参与者根据该比值分为四分位数。采用多因素逻辑回归和受限立方样条分析评估关联。进行亚组分析和交互作用检验。
HUA患病率随CRP/HDL-c四分位数升高而增加（分别为18.43%、20.39%、24.54%和29.82%；P<0.001）。较高的CRP/HDL-c水平与HUA风险增加独立相关（比值比[OR]=1.64，95%置信区间[CI]：1.14-2.36；P=0.008）。与最低四分位数的参与者相比，最高四分位数的参与者风险显著更高（OR=1.33，95%CI：1.15-1.54；P<0.001）。女性中的关联（OR=1.30）比男性（OR=1.14）更强，存在显著的性别交互作用（交互作用P=0.031）。在女性中，该关联在年龄<50岁者中更明显（OR=1.47）。受限立方样条分析表明存在线性剂量反应关系。
C反应蛋白与高密度脂蛋白胆固醇比值升高与糖尿病或糖尿病前期成年人高尿酸血症风险较高显著相关，尤其是年轻女性。
