Battaglia G, Di Mario F, Cannizzaro R, Farinati R, Braghetto D, La Rosa G, Martin A, Naccarato R
Acta Gastroenterol Belg. 1988 Jul-Oct;51(4-5):322-8.
No extensive endoscopic studies have been performed on the prevalence and the clinical outcome of association of gastric ulcer (GU) and duodenal ulcer (DU). The present investigation, partially retrospective and partially prospective, takes into account 715 patients with active ulcer demonstrated by endoscopy, followed-up for a mean period of 3.8-years; 23 of them (3.2%) were found to have synchronous or asynchronous gastric and duodenal ulcers. The following characteristics were investigated: age of onset of both diseases, ulcer family history, cigarette and alcohol consumption, nonsteroidal anti-inflammatory drugs abuse, serum pepsinogen group I, ABO and Lewis blood groups, healing and relapse rate under H2-blocker treatment. The first diagnosis (by either X-Ray or endoscopy) was DU in 500 subjects (70%), GU in 210 (29.3%) and synchronous gastric and duodenal ulcers in 5 (0.7%). After a median period of 10 years, 2.8% of DU patients developed a GU; after 2-12 yrs 1.9% of GU patients developed a DU. The clinical and biochemical findings of our GU/DU patients suggest that the two ulcers are related by chance.
asynchronous GU/DU patients do not seem to have a distinct disease in the large spectrum of ulcer disease. Larger studies must be planned on synchronous GU/DU with the aim of assessing whether or not it represents a particular type of ulcer disease.
尚未针对胃溃疡（GU）和十二指肠溃疡（DU）合并存在的患病率及临床结局进行广泛的内镜研究。本项研究部分为回顾性研究，部分为前瞻性研究，纳入了715例经内镜证实为活动性溃疡的患者，平均随访3.8年；其中23例（3.2%）被发现患有同步或异时性胃和十二指肠溃疡。研究了以下特征：两种疾病的发病年龄、溃疡家族史、吸烟和饮酒情况、非甾体抗炎药滥用情况、血清胃蛋白酶原I组、ABO和Lewis血型、H2受体阻滞剂治疗下的愈合率和复发率。首次诊断（通过X线或内镜）为DU的有500例（70%），GU的有210例（29.3%），同步胃和十二指肠溃疡的有5例（0.7%）。经过中位时间10年，2.8%的DU患者发生了GU；2至12年后，1.9%的GU患者发生了DU。我们的GU/DU患者的临床和生化检查结果提示这两种溃疡是偶然相关的。
异时性GU/DU患者在广泛的溃疡病谱中似乎没有一种独特的疾病。必须针对同步性GU/DU开展更大规模的研究，以评估其是否代表一种特殊类型的溃疡病。
