酰胺捕获 N-酰亚胺离子：一种中到大环二氮杂杂环的方法。
Trapping of N-Acyliminium Ions with Enamides: An Approach to Medium-Sized Diaza-Heterocycles.
机构信息
Laboratoire de Chimie Organique Synthétique , Institut de Chimie, CNRS-UdS, UMR 7177 , 4, rue Blaise Pascal, CS 90032 , 67081 Strasbourg , France.
出版信息
Org Lett. 2018 Jun 1;20(11):3430-3433. doi: 10.1021/acs.orglett.8b01407. Epub 2018 May 23.
PMID:29790768
Abstract
Enamides equipped with N-acyliminium ion precursors were obtained through reduction of ynamides tethered to N-imides. Intramolecular TMSOTf-mediated trapping of N-acyliminium ions provided a variety of polyfunctionalized medium-sized diaza-heterocycles of putative pharmacological interest.
摘要
通过还原与 N-酰亚胺键合的炔酰胺，得到了带有 N-酰亚胺离子前体的 enamides。TMSOTf 介导的 N-酰亚胺离子的分子内捕获提供了多种具有潜在药理意义的多功能化中到大环二氮杂杂环化合物。
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