Yücel Oğuzhan, Güneş Hakan, Yücel Hasan, Zorlu Ali
Department of Cardiology, Anatolian Hospital Samsun, Turkey.
Department of Cardiology, Kahramanmaraş Sütçü İmam Üniversitesi, Kahramanmaraş, Turkey.
Sao Paulo Med J. 2018 Mar;136(2):140-143. doi: 10.1590/1516-3180.2017.0299281017.
Right ventricular (RV) dysfunction may develop over the course of chronic obstructive pulmonary disease (COPD) and is an important predictor of morbidity and mortality. Polymorphism of the multidrug resistance-1 (MDR-1) gene has been correlated with worse clinical findings among patients with COPD. Our aim here was to investigate the relationship between MDR-1 C3435T gene polymorphism and RV dysfunction in COPD patients.
This was a cross-sectional study investigating the relationship between RV dysfunction and genetic defects in COPD patients.
Forty-one consecutive patients diagnosed with COPD and hospitalized due to acute exacerbation were enrolled. Polymorphism was analyzed using the strip assay technique. RV parameters were evaluated, and RV dysfunction was identified via transthoracic echocardiography. Patients were categorized into three groups according to gene polymorphism: MDR-1 CC (wild type, n = 9), MDR-1 CT (heterozygote mutant, n = 21) or MDR-1 TT (homozygote mutant, n = 11).
The study included 14 males and 27 females (mean age 65 ± 11 years). The mean systolic pulmonary artery pressure was 31.4 ± 8 mmHg in the wild-type group, 42.2 ± 12 mmHg in the heterozygote mutant group and 46.5±14 mmHg in the homozygote mutant group (P = 0.027). Presence of RV dilatation was significantly different among the three groups (33%, 71%, and 100%, respectively; P = 0.005). In multiple logistic regression analysis, MDR-1 C3435T gene polymorphism (OR = 9.000, P = 0.019) was an independent predictor of RV dysfunction after adjustment for potential confounders.
MDR-1 C3435T gene polymorphism was associated with RV dysfunction in patients with COPD.
右心室（RV）功能障碍可能在慢性阻塞性肺疾病（COPD）病程中出现，并且是发病率和死亡率的重要预测指标。多药耐药-1（MDR-1）基因多态性与COPD患者较差的临床结局相关。我们在此的目的是研究COPD患者中MDR-1 C3435T基因多态性与RV功能障碍之间的关系。
这是一项横断面研究，旨在调查COPD患者中RV功能障碍与基因缺陷之间的关系。
纳入41例因急性加重而诊断为COPD并住院的连续患者。使用条带分析技术分析多态性。评估RV参数，并通过经胸超声心动图识别RV功能障碍。根据基因多态性将患者分为三组：MDR-1 CC（野生型，n = 9）、MDR-1 CT（杂合子突变型，n = 21）或MDR-1 TT（纯合子突变型，n = 11）。
该研究包括14名男性和27名女性（平均年龄65±11岁）。野生型组的平均收缩期肺动脉压为31.4±8 mmHg，杂合子突变型组为42.2±12 mmHg，纯合子突变型组为46.5±14 mmHg（P = 0.027）。三组之间RV扩张的存在情况有显著差异（分别为33%、71%和100%；P = 0.005）。在多因素逻辑回归分析中，在对潜在混杂因素进行调整后，MDR-1 C3435T基因多态性（OR = 9.000，P = 0.019）是RV功能障碍的独立预测指标。
MDR-1 C3435T基因多态性与COPD患者的RV功能障碍相关。
