Department of Nursing, Ryazan State Medical University, 390026 Ryazan, Russia.
Department of Pharmacology and Pharmacy, Ryazan State Medical University, 390026 Ryazan, Russia.
Int J Mol Sci. 2021 Jun 23;22(13):6711. doi: 10.3390/ijms22136711.
Chronic obstructive pulmonary disease (COPD) ranks among the leading causes of morbidity and mortality worldwide. COPD rarely occurs in isolation and is often combined with various diseases. It is considered that systemic inflammation underlies the comorbid course of COPD. The data obtained in recent years have shown the importance of violations of the cross-links of lipid metabolism and the immune response, which are links in the pathogenesis of both COPD and atherosclerosis. The role of lipid metabolism disorders in the pathogenesis of the comorbid course of COPD and atherosclerosis and the participation of ATP-binding cassette (ABC) transporters in these processes is discussed in this article. It is known that about 20 representatives of a large family of ABC transporters provide lipid homeostasis of cells by moving lipids inside the cell and in its plasma membrane, as well as removing lipids from the cell. It was shown that some representatives of the ABC-transporter family are involved in various links of the pathogenesis of COPD and atherosclerosis, which can determine their comorbid course.
慢性阻塞性肺疾病（COPD）是全球发病率和死亡率的主要原因之一。COPD 很少单独发生，通常与各种疾病同时存在。据认为，系统性炎症是 COPD 合并症发生的基础。近年来获得的数据表明，脂代谢和免疫反应交联的破坏具有重要意义，这是 COPD 和动脉粥样硬化发病机制中的两个环节。本文讨论了脂代谢紊乱在 COPD 和动脉粥样硬化合并症发病机制中的作用以及三磷酸腺苷结合盒（ABC）转运蛋白在这些过程中的参与。据了解，大约有 20 种 ABC 转运蛋白家族的代表通过在细胞内和其质膜内移动脂质以及从细胞中去除脂质来提供细胞的脂类内稳态。已经表明，ABC 转运蛋白家族的一些代表参与了 COPD 和动脉粥样硬化发病机制的各个环节，这可以决定它们的合并症病程。
