Department of Biotechnology, University of Kashmir, Srinagar, 190006, J&K, India.
Department of Biotechnology, University of Kashmir, Srinagar, 190006, J&K, India.
Int J Biochem Cell Biol. 2018 Aug;101:29-38. doi: 10.1016/j.biocel.2018.05.009. Epub 2018 May 20.
GW182 proteins interact directly with the argonaute proteins and constitute key components of miRNA repressor complexes (miRISC) in metazoans. As argonautes are insufficient for silencing they recruit the GW182 s that act as scaffold proteins inducing downstream translational repression, target mRNA deadenylation and exonucleolytic mRNA degradation. Besides their role as part of repressor complexes inside the cell, they function in wide variety of cellular processes as highlighted in this review. The present review summarises and discusses in detail our current knowledge of the GW182 s and their role inside the cell.
GW182 蛋白与 argonaute 蛋白直接相互作用，并构成后生动物 miRNA 抑制复合物 (miRISC) 的关键组成部分。由于 argonaute 蛋白不足以沉默，它们招募 GW182s，GW182s 作为支架蛋白诱导下游翻译抑制、靶 mRNA 去腺苷酸化和外切核酸酶 mRNA 降解。除了它们作为细胞内抑制复合物一部分的作用外，GW182s 在多种细胞过程中发挥作用，如本文综述所述。本综述详细总结和讨论了我们目前对 GW182s 及其在细胞内作用的认识。
