宿主 miRNA 与 RNA 病毒内 RNA 的结合对病毒复制的影响。

The Influence of Host miRNA Binding to RNA Within RNA Viruses on Virus Multiplication.

机构信息

Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.

Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.

出版信息

Front Cell Infect Microbiol. 2022 Apr 21;12:802149. doi: 10.3389/fcimb.2022.802149. eCollection 2022.

DOI:10.3389/fcimb.2022.802149

PMID:35531344

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9069554/

Abstract

microRNAs (miRNAs), non-coding RNAs about 22 nt long, regulate the post-transcription expression of genes to influence many cellular processes. The expression of host miRNAs is affected by virus invasion, which also affects virus replication. Increasing evidence has demonstrated that miRNA influences RNA virus multiplication by binding directly to the RNA virus genome. Here, the knowledge relating to miRNAs' relationships between host miRNAs and RNA viruses are discussed.

摘要

microRNAs (miRNAs)，长度约为 22 个核苷酸的非编码 RNA，调节基因的转录后表达，从而影响许多细胞过程。宿主 miRNAs 的表达受病毒入侵的影响，而病毒入侵也会影响病毒的复制。越来越多的证据表明，miRNA 通过直接与 RNA 病毒基因组结合来影响 RNA 病毒的复制。本文讨论了宿主 miRNAs 与 RNA 病毒之间的关系。