Institute for Research in Operative Medicine, Witten/Herdecke University, Ostmerheimer Str. 200, 51109, Cologne, Germany.
AQUA Institute for Applied Quality Improvement and Research in Health Care, Maschmuehlenweg 8-10, 37073, Goettingen, Germany.
Syst Rev. 2018 May 23;7(1):79. doi: 10.1186/s13643-018-0743-4.
Conducting a health technology assessment (HTA) of public health interventions (PHIs) poses some challenges. PHIs are often complex interventions, which affect the number and degree of interactions of the aspects to be assessed. Randomized controlled trials on PHIs are rare as they are difficult to conduct because of ethical or feasibility issues. The aim of this study is to provide an overview of the methodological characteristics and to compare the applied assessment methods in HTAs on PHIs.
We will systematically search HTA agencies for HTAs on PHIs published between 2012 and 2016. We will identify the HTAs by screening the webpages of members of international HTA organizations. One reviewer will screen the list of HTAs on the webpages of members of international HTA organization, and a second review will double-check the excluded records. For this methodological review, we define a PHI as a population-based intervention on health promotion or for primary prevention of chronic or non-chronic diseases. Only full HTA reports will be included. At maximum, we will include a sample of 100 HTAs. In the case that we identify more than 100 relevant HTAs, we will perform a random selection. We will extract data on effectiveness, safety and economic as well as on social, cultural, ethical and legal aspects in a priori piloted standardized tables. We will not assess the risk of bias as we focus on exploring methodological features. Data extraction will be performed by one reviewer and verified by a second. We will synthesize data using tables and in a structured narrative way.
Our analysis will provide a comprehensive and current overview of methods applied in HTAs on PHIs. We will discuss approaches that may be promising to overcome the challenges of evaluating PHIs.
进行公共卫生干预措施（PHIs）的卫生技术评估（HTA）存在一些挑战。PHIs 通常是复杂的干预措施，会影响到需要评估的各个方面的数量和相互作用程度。由于伦理或可行性问题，针对 PHIs 的随机对照试验很少，因为它们很难进行。本研究的目的是提供一个方法学特征概述，并比较 PHI 的 HTA 中应用的评估方法。
我们将系统地在 2012 年至 2016 年间，对 HTA 机构进行关于 PHI 的 HTA 搜索。我们将通过筛选国际 HTA 组织成员的网页来识别这些 HTA。一位审查员将筛选国际 HTA 组织成员网页上的 HTA 列表，第二位审查员将对排除的记录进行双重检查。在本方法学审查中，我们将基于人群的健康促进干预措施或慢性病或非慢性病的初级预防干预措施定义为 PHI。只有完整的 HTA 报告才会被包括在内。在我们确定超过 100 项相关 HTA 的情况下，我们将进行随机选择。我们将在预先制定的标准化表格中提取有效性、安全性和经济学以及社会、文化、伦理和法律方面的数据。我们不会评估偏倚风险，因为我们专注于探索方法学特征。数据提取将由一名审查员进行，并由第二名审查员进行验证。我们将使用表格和结构化叙述的方式综合数据。
我们的分析将提供一个关于 PHI 的 HTA 中应用的方法的全面和最新概述。我们将讨论可能有希望克服评估 PHI 挑战的方法。
