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The effects of the 5-hydroxytryptamine (5HT3) receptor antagonist ICS 205-930 in the carcinoid syndrome.

作者信息

Coupe M O, Anderson J V, Morris J A, Alstead E M, Bloom S R, Hodgson H J

机构信息

Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.

出版信息

Aliment Pharmacol Ther. 1988 Apr;2(2):167-72. doi: 10.1111/j.1365-2036.1988.tb00684.x.

DOI:10.1111/j.1365-2036.1988.tb00684.x
PMID:2979242
Abstract

Therapy for diarrhoea associated with the carcinoid syndrome is often unsatisfactory. In an open study ICS 205-930 (Sandoz Limited), a novel 5HT3-antagonist, controlled diarrhoea in five of six patients studied. This drug may be a useful advance in the symptomatic treatment of the carcinoid syndrome.

摘要

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What Is Carcinoid Syndrome? A Critical Appraisal of Its Proposed Mediators.类癌综合征是什么?对其拟议介质的批判性评估。
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Effects of the 5-HT3 antagonist cilansetron vs placebo on phasic sigmoid colonic motility in healthy man: a double-blind crossover trial.5-羟色胺3受体拮抗剂西兰司琼与安慰剂对健康男性乙状结肠阶段性运动的影响:一项双盲交叉试验
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Medium-term effects of a new 5HT3 antagonist, alosetron, in patients with carcinoid diarrhoea.
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Controlling the carcinoid syndrome.控制类癌综合征。
BMJ. 1988 Nov 12;297(6658):1213-4. doi: 10.1136/bmj.297.6658.1213.