Schwörer H, Münke H, Stöckmann F, Ramadori G
Department of Medicine, University of Göttingen, Germany.
Am J Gastroenterol. 1995 Apr;90(4):645-8.
A 69-yr-old man with known carcinoid syndrome treated with octreotide and interferon-alpha 2b developed diarrhea, with six to eight watery to semiliquid stools per day. Diminished stool frequency and increased stool consistency were obtained by treatment with the 5-hydroxytryptamine-3 receptor antagonists ondansetron and tropisetron. Successful alleviation of the diarrhea was also observed with the alpha 2-receptor agonist clonidine. These observations indicate that these classes of drugs should be evaluated in a controlled trial in patients with carcinoid-associated diarrhea.
一名69岁已知患有类癌综合征的男性，接受奥曲肽和α-干扰素2b治疗后出现腹泻，每天有6至8次水样便或半流质便。使用5-羟色胺-3受体拮抗剂昂丹司琼和托烷司琼治疗后，排便次数减少，粪便稠度增加。使用α2受体激动剂可乐定也成功缓解了腹泻。这些观察结果表明，应在一项针对类癌相关性腹泻患者的对照试验中对这类药物进行评估。
