Faculty of Social and Behavioral Sciences, Leiden University, Leiden, The Netherlands; Leiden Institute for Brain and Cognition, Leiden University Medical Center, Leiden, The Netherlands; Department of Psychology, Education, and Child Studies, Erasmus University Rotterdam, Rotterdam, The Netherlands.
Faculty of Social and Behavioral Sciences, Leiden University, Leiden, The Netherlands; Leiden Institute for Brain and Cognition, Leiden University Medical Center, Leiden, The Netherlands.
Horm Behav. 2018 Jul;103:19-27. doi: 10.1016/j.yhbeh.2018.05.014. Epub 2018 Jun 1.
In a randomized, double blind, placebo-controlled, within-subject magnetic resonance imaging study, we examined the effect of 20 IU intranasal vasopressin on the neural processing of infant crying in 25 fathers-to-be. We explored whether familial background modulates vasopressin effects, and whether vasopressin differentially affects cry processing coupled with neutral or emotional contextual information. Participants listened to cries accompanied by neutral ('this is an infant') or emotional ('this infant is sick/bored') contextual information, and neutral control sounds ('this is a saw'). Additionally, participants reported on their childhood experiences of parental love-withdrawal and abuse. Infant crying (vs control sounds) was associated with increased activation in the bilateral auditory cortex and posterior medial cortex. No effects of vasopressin were found in this 'cry network'. Exploratory whole-brain analyses suggested that effects of vasopressin in the anterior cingulate cortex, paracingulate gyrus and supplemental motor area were stronger in fathers who experienced lower (vs higher) levels of love-withdrawal. No interaction was observed for abuse. Vasopressin increased activation in response to cries accompanied by emotional vs neutral contextual information in several brain regions, e.g. the cerebellum, brainstem (midbrain), posterior medial cortex, hippocampus, putamen, and insula. Our results suggest that the experience of love-withdrawal may modulate the vasopressin system, influencing effects of vasopressin administration on cry processing. Results further suggest a role for vasopressin in the processing of cry sounds with emotional contextual information.
在一项随机、双盲、安慰剂对照、自身对照的磁共振成像研究中，我们研究了 20IU 鼻内血管加压素对 25 名准父亲对婴儿哭声的神经处理的影响。我们探讨了家族背景是否调节血管加压素的作用，以及血管加压素是否对与中性或情感性背景信息相结合的哭声处理产生不同的影响。参与者听伴随着中性（“这是一个婴儿”）或情感（“这个婴儿生病了/无聊”）背景信息的哭声，以及中性对照声音（“这是锯子”）。此外，参与者还报告了他们童年时期父母爱与回避和虐待的经历。与对照声音相比，婴儿哭声（vs 控制声音）与双侧听觉皮层和后内侧皮层的激活增加有关。在这个“哭声网络”中没有发现血管加压素的作用。探索性全脑分析表明，在前扣带皮层、旁中央回和补充运动区，血管加压素的作用在经历较低（vs 较高）水平爱与回避的父亲中更强。未观察到虐待的相互作用。与中性背景信息相比，血管加压素增加了对伴随情感背景信息的哭声的反应，在几个脑区（如小脑、脑干（中脑）、后内侧皮层、海马体、壳核和脑岛）中观察到这种反应。我们的研究结果表明，爱与回避的经历可能调节血管加压素系统，影响血管加压素给药对哭声处理的影响。研究结果进一步表明，血管加压素在处理具有情感背景信息的哭声方面发挥作用。
